Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

Modifications of lean mass are a frequent critical determinant in the pathophysiology and
progression of heart failure (HF). Sarcopenia may be considered one of the most important …

Up to 50% of cancer patients suffer from a progressive atrophy of adipose tissue and
skeletal muscle, called cachexia, resulting in weight loss, a reduced quality of life, and a …

Since the first identification of renin by Tigerstedt and Bergmann in 1898, the renin-
angiotensin system (RAS) has been extensively studied. The current view of the system is …

Skeletal muscle atrophy is a pathological condition mainly characterized by a loss of
muscular mass and the contractile capacity of the skeletal muscle as a consequence of …

A characteristic feature of aged humans and other mammals is the debilitating, progressive
loss of skeletal muscle function and mass that is known as sarcopenia. Age-related muscle …

Background Ghrelin is a novel growth hormone (GH)-releasing peptide, isolated from the
stomach, that may also cause a positive energy balance by stimulating food intake and …

Chronic kidney disease (CKD), a chronic catabolic condition, is characterized by muscle
wasting and decreased muscle endurance. Many insights into the molecular mechanisms of …

Advanced congestive heart failure is associated with activation of the renin-angiotensin
system and skeletal muscle wasting. We previously showed that angiotensin II infusion in …

Animal studies suggest that increased levels of circulating angiotensin II (AngII) could
contribute to the loss of lean body mass in chronic kidney disease, but the mechanism by …