How the immune system shapes atherosclerosis: roles of innate and adaptive immunity

P Roy, M Orecchioni, K Ley - Nature Reviews Immunology, 2022 - nature.com
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …

Immunity and inflammation in atherosclerosis

D Wolf, K Ley - Circulation research, 2019 - Am Heart Assoc
There is now overwhelming experimental and clinical evidence that atherosclerosis is a
chronic inflammatory disease. Lessons from genome-wide association studies, advanced in …

T cell subsets and functions in atherosclerosis

R Saigusa, H Winkels, K Ley - Nature Reviews Cardiology, 2020 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …

Autoimmunity and organ damage in systemic lupus erythematosus

GC Tsokos - Nature immunology, 2020 - nature.com
Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …

Meta-analysis of leukocyte diversity in atherosclerotic mouse aortas

A Zernecke, H Winkels, C Cochain… - Circulation …, 2020 - Am Heart Assoc
The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …

Monocyte-macrophages and T cells in atherosclerosis

I Tabas, AH Lichtman - Immunity, 2017 - cell.com
Atherosclerosis is an arterial disease process characterized by the focal subendothelial
accumulation of apolipoprotein-B-containing lipoproteins, immune and vascular wall cells …

Identification of human exTreg cells as CD16+CD56+ cytotoxic CD4+ T cells

A Freuchet, P Roy, SS Armstrong, M Oliaeimotlagh… - Nature …, 2023 - nature.com
In atherosclerosis, some regulatory T (Treg) cells become exTreg cells. We crossed
inducible Treg and exTreg cell lineage-tracker mice (FoxP3 eGFP− Cre-ERT2 ROSA26 CAG …

Atlas of the immune cell repertoire in mouse atherosclerosis defined by single-cell RNA-sequencing and mass cytometry

H Winkels, E Ehinger, M Vassallo, K Buscher… - Circulation …, 2018 - Am Heart Assoc
Rationale: Atherosclerosis is a chronic inflammatory disease that is driven by the interplay of
pro-and anti-inflammatory leukocytes in the aorta. Yet, the phenotypic and transcriptional …

Vascular endothelial cells and innate immunity

Y Shao, J Saredy, WY Yang, Y Sun, Y Lu… - … , and vascular biology, 2020 - Am Heart Assoc
In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …

Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100–Reactive CD4+ T-Regulatory Cells

D Wolf, T Gerhardt, H Winkels, NA Michel, AB Pramod… - Circulation, 2020 - Am Heart Assoc
Background: Throughout the inflammatory response that accompanies atherosclerosis,
autoreactive CD4+ T-helper cells accumulate in the atherosclerotic plaque. Apolipoprotein …