How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …
preclinical models and emerging evidence in humans have established the crucial roles of …
Immunity and inflammation in atherosclerosis
There is now overwhelming experimental and clinical evidence that atherosclerosis is a
chronic inflammatory disease. Lessons from genome-wide association studies, advanced in …
chronic inflammatory disease. Lessons from genome-wide association studies, advanced in …
T cell subsets and functions in atherosclerosis
Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …
Autoimmunity and organ damage in systemic lupus erythematosus
GC Tsokos - Nature immunology, 2020 - nature.com
Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …
almost every aspect of the immune system contributes to the expression of systemic …
Meta-analysis of leukocyte diversity in atherosclerotic mouse aortas
The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …
Monocyte-macrophages and T cells in atherosclerosis
I Tabas, AH Lichtman - Immunity, 2017 - cell.com
Atherosclerosis is an arterial disease process characterized by the focal subendothelial
accumulation of apolipoprotein-B-containing lipoproteins, immune and vascular wall cells …
accumulation of apolipoprotein-B-containing lipoproteins, immune and vascular wall cells …
Identification of human exTreg cells as CD16+CD56+ cytotoxic CD4+ T cells
In atherosclerosis, some regulatory T (Treg) cells become exTreg cells. We crossed
inducible Treg and exTreg cell lineage-tracker mice (FoxP3 eGFP− Cre-ERT2 ROSA26 CAG …
inducible Treg and exTreg cell lineage-tracker mice (FoxP3 eGFP− Cre-ERT2 ROSA26 CAG …
Atlas of the immune cell repertoire in mouse atherosclerosis defined by single-cell RNA-sequencing and mass cytometry
Rationale: Atherosclerosis is a chronic inflammatory disease that is driven by the interplay of
pro-and anti-inflammatory leukocytes in the aorta. Yet, the phenotypic and transcriptional …
pro-and anti-inflammatory leukocytes in the aorta. Yet, the phenotypic and transcriptional …
Vascular endothelial cells and innate immunity
In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …
participate in both innate and adaptive immune responses. We previously reported that, in …
Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100–Reactive CD4+ T-Regulatory Cells
Background: Throughout the inflammatory response that accompanies atherosclerosis,
autoreactive CD4+ T-helper cells accumulate in the atherosclerotic plaque. Apolipoprotein …
autoreactive CD4+ T-helper cells accumulate in the atherosclerotic plaque. Apolipoprotein …