Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years

M Maccarrone, V Di Marzo, J Gertsch, U Grether… - Pharmacological …, 2023 - ASPET
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

Endocannabinoid system: chemical characteristics and biological activity

B Rezende, AKN Alencar, GF de Bem… - Pharmaceuticals, 2023 - mdpi.com
The endocannabinoid system (eCB) has been studied to identify the molecular structures
present in Cannabis sativa. eCB consists of cannabinoid receptors, endogenous ligands …

Parallel evolution of cannabinoid biosynthesis

P Berman, LA de Haro, A Jozwiak, S Panda, Z Pinkas… - Nature plants, 2023 - nature.com
Modulation of the endocannabinoid system is projected to have therapeutic potential in
almost all human diseases. Accordingly, the high demand for novel cannabinoids stimulates …

An individuality of response to cannabinoids: challenges in safety and efficacy of cannabis products

S Kitdumrongthum, D Trachootham - Molecules, 2023 - mdpi.com
Since legalization, cannabis/marijuana has been gaining considerable attention as a
functional ingredient in food.∆-9 tetrahydrocannabinol (THC), cannabidiol (CBD), and other …

Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn't

C Christensen, M Rose, C Cornett, M Allesø - Biomedicines, 2023 - mdpi.com
The 'entourage effect'term was originally coined in a pre-clinical study observing
endogenous bio-inactive metabolites potentiating the activity of a bioactive …

The pharmacology and therapeutic role of cannabidiol in diabetes

J Zhang, C Lin, S Jin, H Wang, Y Wang, X Du… - …, 2023 - Wiley Online Library
In recent years, cannabidiol (CBD), a non‐psychotropic cannabinoid, has garnered
substantial interest in drug development due to its broad pharmacological activity and multi …

The effect of cannabis plant extracts on head and neck squamous cell carcinoma and the quest for cannabis-based personalized therapy

K Blal, E Besser, S Procaccia, O Schwob, Y Lerenthal… - Cancers, 2023 - mdpi.com
Simple Summary The survival rate of head and neck cancer has only improved slightly over
the last quarter century, raising the need for novel therapies to better treat this disease. This …

Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression

I Wyrobnik, M Steinberg, A Gelfand… - …, 2023 - Taylor & Francis
During solid tumor progression, the tumor microenvironment (TME) evolves into a highly
immunosuppressive milieu. Key players in the immunosuppressive environment are …

Encapsulation of Hemp (Cannabis sativa L.) Essential Oils into Nanoemulsions for Potential Therapeutic Applications: Assessment of Cytotoxicological Profiles

C Aguzzi, DR Perinelli, M Cespi, L Zeppa, E Mazzara… - Molecules, 2023 - mdpi.com
Industrial hemp (Cannabis sativa L.), due to its bioactive compounds (terpenes and
cannabinoids), has gained increasing interest in different fields, including for medical …

Cannabidiol and Tetrahydrocannabinol Antinociceptive Activity is Mediated by Distinct Receptors in Caenorhabditis elegans

F Boujenoui, B Nkambeu, JB Salem… - Neurochemical …, 2024 - Springer
Cannabis has gained popularity in recent years as a substitute treatment for pain following
the risks of typical treatments uncovered by the opioid crisis. The active ingredients …