Genetic studies suggest that sequential dissemination from a primary metastasis, usually at
the bone, is a major route of metastatic progression in early, radically resected cancer …

Ferroptosis is a form of regulated cell death characterized by iron overload, overwhelming
lipid peroxidation, and disruption of antioxidant systems. Emerging evidence suggests that …

The molecular basis of disease progression from UV-induced precancerous actinic keratosis
(AK) to malignant invasive cutaneous squamous cell carcinoma (cSCC) and potentially …

The endometrial lining of the uterus is essential for women's reproductive health and
consists of several different types of epithelial and stromal cells. Although models such as …

A hallmark of primate postimplantation embryogenesis is the specification of extraembryonic
mesoderm (EXM) before gastrulation, in contrast to rodents where this tissue is formed only …

Growing evidence suggests that the presence of cancer stem cells (CSCs) is a major
challenge in current tumor treatments, especially the transition from non-CSCs to …

Mechanisms specifying amniotic ectoderm and surface ectoderm are unresolved in humans
due to their close similarities in expression patterns and signal requirements. This lack of …

Background: Hepatocellular carcinoma (HCC) is among the deadliest cancers worldwide,
and advanced HCC is difficult to treat. Identifying specific cell subpopulations in the tumor …

Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare pancreatic tumor in
children. Its origin remains elusive, along with its pathogenesis. Heterogeneity within SPN …

Cancer stemness is recognized as a key component of tumor development. Previously
coined" cancer stem cells"(CSCs) and believed to be a rare population with rigid …