Cranial placodes are specialized regions of the ectoderm, which give rise to various sensory
ganglia and contribute to the pituitary gland and sensory organs of the vertebrate head …

The sine oculis homeobox (SIX) protein family is a group of evolutionarily conserved
transcription factors that are found in diverse organisms that range from flatworms to …

We report here development of a novel gene trap method in zebrafish using the Tol2
transposon system. First, we established a highly efficient transgenesis method in which a …

In vertebrate embryos, formation of anterior neural structures requires suppression of Wnt
signals emanating from the paraxial mesoderm and midbrain territory. In Six3−/− mice, the …

Abstract Background: The transcription factor Nrf2 and its negative regulator Keap1 play
important roles in transcriptional induction of a set of detoxifying and anti‐oxidant enzymes …

Zebrafish is an excellent model animal to study vertebrate development by genetic
approaches. Hundreds of mutations affecting various processes of development have been …

For a long time, it has been understood that neurogenesis is linked to proliferation and thus
to the cell cycle. Recently, the gears that mediate this linkage have become accessible to …

Free swimming zebrafish larvae depend mainly on their sense of vision to evade predation
and to catch prey. Hence, there is strong selective pressure on the fast maturation of visual …

Publisher Summary This chapter focuses on transgenesis and gene trap methods in
zebrafish by using the Tol2 transposable element. Zebrafish (Danio rerio) has been used as …

Abstract Recent years have seen a renaissance of investigation into the mechanisms of
inner ear development. Genetic analysis of zebrafish has contributed significantly to this …