[HTML][HTML] SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …

[HTML][HTML] Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - Nature reviews Molecular …, 2022 - nature.com
The unprecedented public health and economic impact of the COVID-19 pandemic caused
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …

[HTML][HTML] The origins of SARS-CoV-2: A critical review

EC Holmes, SA Goldstein, AL Rasmussen… - Cell, 2021 - cell.com
Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus
in December 2019 in Wuhan, China, there has been intense interest in understanding how …

[HTML][HTML] The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

TP Peacock, DH Goldhill, J Zhou, L Baillon… - Nature …, 2021 - nature.com
SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and
the S2ʹ cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion …

[HTML][HTML] Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

RE Chen, X Zhang, JB Case, ES Winkler, Y Liu… - Nature medicine, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global
COVID-19 pandemic. Rapidly spreading SARS-CoV-2 variants may jeopardize newly …

[HTML][HTML] Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

J Dong, SJ Zost, AJ Greaney, TN Starr… - Nature …, 2021 - nature.com
Understanding the molecular basis for immune recognition of SARS-CoV-2 spike
glycoprotein antigenic sites will inform the development of improved therapeutics. We …

[HTML][HTML] Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant

X Deng, MA Garcia-Knight, MM Khalid, V Servellita… - Cell, 2021 - cell.com
We identified an emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples …

[HTML][HTML] Escape of SARS-CoV-2 501Y. V2 from neutralization by convalescent plasma

S Cele, I Gazy, L Jackson, SH Hwa, H Tegally, G Lustig… - Nature, 2021 - nature.com
SARS-CoV-2 variants of concern (VOC) have arisen independently at multiple locations,
and may reduce the efficacy of current vaccines that target the spike glycoprotein of SARS …

[HTML][HTML] Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

BA Johnson, X Xie, AL Bailey, B Kalveram… - Nature, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—a new coronavirus that
has led to a worldwide pandemic—has a furin cleavage site (PRRAR) in its spike protein …

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape

KR McCarthy, LJ Rennick, S Nambulli… - Science, 2021 - science.org
Zoonotic pandemics, such as that caused by severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), can follow the spillover of animal viruses into highly susceptible human …