Traditionally, idiopathic hypogonadotropic hypogonadism (IHH) is divided into two major
categories: Kallmann syndrome (KS) and normosmic IHH (nIHH). To date, inactivating …

Background Kisspeptin is the leading upstream regulator of pulsatile and surge
Gonadotrophin-Releasing Hormone secretion (GnRH) in the hypothalamus, which acts as …

The neuroendocrine regulation of reproduction is an intricate process requiring the exquisite
coordination of an assortment of cellular networks, all converging on the GnRH neurons …

Context: Delayed puberty (DP) is a common issue and, in the absence of an underlying
condition, is typically self limited. Alhough DP seems to be heritable, no specific genetic …

Congenital hypogonadotropic hypogonadism (CHH) is a clinically and genetically
heterogeneous congenital disease. Symptoms cover a wide spectrum from mild forms to …

Hypogonadotropic hypogonadism (HH) often manifests as pubertal delay. A considerable
proportion of cases of HH is due to genetic mutations. Recognizing those mutated genes …

Human sexual and reproductive development is regulated by the hypothalamic-pituitary-
gonadal (HPG) axis, which is primarily controlled by the gonadotropin-releasing hormone …

Objective To analyze the GNRHR in patients with normosmic isolated hypogonadotropic
hypogonadism (IHH) and constitutional delay of growth and puberty (CDGP). Design …

GnRH is the pivotal hormone in controlling the hypothalamic‐pituitary gonadal (HPG) axis in
humans and other mammalian species. GnRH function is influenced by a multitude of known …

Purpose Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is classified as
Kallmann syndrome (KS) with anosmia and normosmic idiopathic hypogonadotropic …