Cancer immunology and immunotherapy are driving forces of research and development in
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …

Although immunotherapy research to date has focused largely on T cells, there is mounting
evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour …

The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive
clinical outcomes and responses to immunotherapy in cancer. Here, we used spatial …

Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …

The tumor microenvironment (TME) is a heterogeneous, complex organization composed of
tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and …

Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific
immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such …

B-cells play a key role in cancer suppression, particularly when aggregated in tertiary
lymphoid structures (TLS). Here, we investigate the role of B-cells and TLS in endometrial …

Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …

Cancer‐associated fibroblasts (CAFs) have conflicting roles in the suppression and
promotion of cancer. Current research focuses on targeting the undesirable properties of …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with poor 5-year
survival rates, necessitating identification of novel therapeutic targets. Elucidating the …