Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

One of the most notoriously altered genes in human cancer is the tumor-suppressor TP53,
which is mutated with high frequency in more cancers than any other tumor suppressor …

Chemotherapy and radiation often induce a number of cellular responses, such as
apoptosis, autophagy, and senescence. One of the major regulators of these processes is …

Colorectal cancer (CRC) is a severe threat to human health. Ginsenosides such as
ginsenoside Rh4 have been widely studied in the antitumor field. Here, we investigated the …

Background Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in
children and adolescents. The current treatment approach includes neoadjuvant and …

Hepatocellular carcinoma (HCC) is often associated with an inflammatory setting. A plethora
of cytokines are secreted in this milieu, actively contributing to the progression of the …

Ionic liquids (ILs) are known for their unique physicochemical properties. However, despite
the great number of published papers, still little attention has been paid to their biological …

Resistance to chemotherapeutic drugs limits the efficacy of chemotherapy in non–small cell
lung cancer (NSCLC). Autophagy is an essential mechanism which involves in drug …

Breast cancer is now the most prevalent cancer in females, therefore, it is essential to
identify factors affecting its initiation and progression. Mesenchymal stem cells (MSCs) have …

The primary cilium (PC) is a microtubule-based antenna-like organelle projecting from the
surface of the cell membrane. We previously reported that PC formation could be regulated …