Interleukin-10 in cancer immunotherapy: from bench to bedside
MA Salkeni, A Naing - Trends in Cancer, 2023 - cell.com
Abstract Interleukin (IL)-10 was one of the first cytokines to be recognized. However, its
functionality in promoting antitumor immunity was described more recently. Context-and …
functionality in promoting antitumor immunity was described more recently. Context-and …
[HTML][HTML] Regulation of NK cell activation and effector functions by the IL-12 family of cytokines: the case of IL-27
NW Zwirner, A Ziblat - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells are characterized by their ability to detect and induce apoptosis of
susceptible target cells and by secretion of immunoregulatory cytokines such as IFN-γ …
susceptible target cells and by secretion of immunoregulatory cytokines such as IFN-γ …
Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy
Cytokines are important immunotherapeutics with approved drugs for the treatment of
human cancers. However, systemic administration of cytokines often fails to achieve …
human cancers. However, systemic administration of cytokines often fails to achieve …
[HTML][HTML] Dual roles of IL-27 in cancer biology and immunotherapy
IL-27 is a pleiotropic two-chain cytokine, composed of EBI3 and IL-27p28 subunits, which is
structurally related to both IL-12 and IL-6 cytokine families. IL-27 acts through a heterodimer …
structurally related to both IL-12 and IL-6 cytokine families. IL-27 acts through a heterodimer …
[HTML][HTML] IL-27, IL-30, and IL-35: a cytokine triumvirate in cancer
The role of the immune system in anti-tumor immunity cannot be overstated, as it holds the
potential to promote tumor eradication or prevent tumor cell escape. Cytokines are critical to …
potential to promote tumor eradication or prevent tumor cell escape. Cytokines are critical to …
[HTML][HTML] Gene modification strategies for next-generation CAR T cells against solid cancers
Y Tian, Y Li, Y Shao, Y Zhang - Journal of hematology & oncology, 2020 - Springer
Immunotherapies have become the backbone of cancer treatment. Among them, chimeric
antigen receptor (CAR) T cells have demonstrated great success in the treatment of …
antigen receptor (CAR) T cells have demonstrated great success in the treatment of …
Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma …
J Bae, T Hideshima, YT Tai, Y Song, P Richardson… - Leukemia, 2018 - nature.com
Histone deacetylases (HDAC) are therapeutic targets in multiple cancers. ACY241, an
HDAC6 selective inhibitor, has shown anti-multiple myeloma (MM) activity in combination …
HDAC6 selective inhibitor, has shown anti-multiple myeloma (MM) activity in combination …
[HTML][HTML] IL-27 and TCR stimulation promote T cell expression of multiple inhibitory receptors
Inhibitory receptors (IR) are a diverse group of cell surface molecules that modulate T cell
activation, but there are gaps in our knowledge of the cell-extrinsic factors that regulate their …
activation, but there are gaps in our knowledge of the cell-extrinsic factors that regulate their …
IL-27 promotes the expansion of self-renewing CD8+ T cells in persistent viral infection
Chronic infection and cancer are associated with suppressed T cell responses in the
presence of cognate antigen. Recent work identified memory-like CXCR5+ TCF1+ CD8+ T …
presence of cognate antigen. Recent work identified memory-like CXCR5+ TCF1+ CD8+ T …
Immune regulation and cytotoxic T cell activation of IL-10 agonists–Preclinical and clinical experience
M Oft - Seminars in immunology, 2019 - Elsevier
The expansion and activation of tumor antigen reactive CD8+ T cells are primary goals of
immunotherapies for cancer. IL-10 is an anti-inflammatory cytokine with an essential role in …
immunotherapies for cancer. IL-10 is an anti-inflammatory cytokine with an essential role in …