Background Warfarin is a highly efficacious oral anticoagulant, but its use is limited by a well-
founded fear of bleeding. Drug and food interactions are frequently cited as causes of …

Carcinogenesis is a multiyear, multistep, multipath disease of progressive genetic
alterations and associated tissue damage. Chemoprevention is the use of drugs or other …

Background: The interaction between warfarin and nonsteroidal antiinflammatory drugs
(NSAIDs) is well known. However, warfarin and NSAIDs are still commonly prescribed …

Background. Rofecoxib and meloxicam are classified as cyclo-oxygenase (COX)-2 selective
inhibitors. The Drug Safety Research Unit (DSRU) monitored the post-marketing safety of …

The elucidation of inducible cyclooxygen-ase (Cox-2) dependent inflammatory pathways led
to the development of specific Cox-2 inhibitors, the coxibs. These agents include the …

Management of warfarin drug interactions is often complicated by lack of information
regarding interactions with new drugs and with herbal medicinals. The pharmaceutical …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to interact with the oral
anticoagulant warfarin and can cause a serious bleeding complication. In this study, we …

NSAIDs are reported to increase the risk of bleeding in coumarin users. The mechanism
underlying this risk is inhibition of platelet aggregation, however a pharmacokinetic …

NSAIDs are extensively used worldwide; nonetheless, they are associated with adverse
gastrointestinal (GI) effects. COX-2 inhibitors (coxibs) have been developed to reduce pain …

Thus, for warfarin, Cl is equal to the product of fu and Clint. Notice that, because Cl~ fu
(Clint), changes in Q do not greatly affect warfarin Cl, Css, avg, Css, u, avg, or …