The influence of neuroinflammation in Autism Spectrum Disorder
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised
by deficits in social communication and restricted or repetitive behaviours. The clinical …
by deficits in social communication and restricted or repetitive behaviours. The clinical …
Microglial/Macrophage polarization and function in brain injury and repair after stroke
Stroke is a leading cause of disability and mortality, with limited treatment options. After
stroke injury, microglia and CNS‐resident macrophages are rapidly activated and regulate …
stroke injury, microglia and CNS‐resident macrophages are rapidly activated and regulate …
[HTML][HTML] An in vivo neuroimmune organoid model to study human microglia phenotypes
Microglia are specialized brain-resident macrophages that play crucial roles in brain
development, homeostasis, and disease. However, until now, the ability to model …
development, homeostasis, and disease. However, until now, the ability to model …
Classification of microglial morphological phenotypes using machine learning
J Leyh, S Paeschke, B Mages, D Michalski… - Frontiers in cellular …, 2021 - frontiersin.org
Microglia are the brain's immunocompetent macrophages with a unique feature that allows
surveillance of the surrounding microenvironment and subsequent reactions to tissue …
surveillance of the surrounding microenvironment and subsequent reactions to tissue …
Microglia morphological categorization in a rat model of neuroinflammation by hierarchical cluster and principal components analysis
MM Fernández-Arjona, JM Grondona… - Frontiers in cellular …, 2017 - frontiersin.org
It is known that microglia morphology and function are closely related, but only few studies
have objectively described different morphological subtypes. To address this issue …
have objectively described different morphological subtypes. To address this issue …
Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba‐1 or GFAP immunoreactivity following systemic immune challenge
Activation of the peripheral immune system elicits a coordinated response from the central
nervous system. Key to this immune to brain communication is that glia, microglia, and …
nervous system. Key to this immune to brain communication is that glia, microglia, and …
A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes
Environmental cues influence the highly dynamic morphology of microglia. Strategies to
characterize these changes usually involve user-selected morphometric features, which …
characterize these changes usually involve user-selected morphometric features, which …
Neuroinflammation and protein pathology in Parkinson's disease dementia
A Kouli, M Camacho, K Allinson… - Acta neuropathologica …, 2020 - Springer
Parkinson's disease dementia is neuropathologically characterized by aggregates of α-
synuclein (Lewy bodies) in limbic and neocortical areas of the brain with additional …
synuclein (Lewy bodies) in limbic and neocortical areas of the brain with additional …
Plasticity of microglia
Microglial cells are the scions of foetal macrophages which invade the neural tube early
during embryogenesis. The nervous tissue environment instigates the phenotypic …
during embryogenesis. The nervous tissue environment instigates the phenotypic …
Inflammatory response leads to neuronal death in human post-mortem cerebral cortex in patients with COVID-19
ME Boroujeni, L Simani, HAR Bluyssen… - ACS chemical …, 2021 - ACS Publications
The recent coronavirus disease of 2019 (COVID-19) pandemic has adversely affected
people worldwide. A growing body of literature suggests the neurological complications and …
people worldwide. A growing body of literature suggests the neurological complications and …