Remyelination is a major therapeutic goal in human myelin disorders, serving to restore
function to demyelinated axons and providing neuroprotection. The target disorders that …

The vertebrate nervous system is characterized by ensheathment of axons with myelin, a
multilamellar membrane greatly enriched in the galactolipid galactocerebroside (GalC) and …

Schwann cells are excluded from the CNS during development by the glial limiting
membrane, an area of astrocytic specialisation present at the nerve root transitional zone …

Myelin-forming oligodendrocytes facilitate saltatory nerve conduction and support neuronal
functions in the mammalian CNS. Although the processes of oligodendrogliogenesis and …

Cross-relaxation imaging (CRI) is a quantitative magnetic resonance technique that
measures the kinetic parameters of magnetization transfer between protons bound to water …

We report neuropathological, biochemical and molecular studies on two patients with
childhood ataxia with diffuse central nervous system hypomyelination (CACH) syndrome, a …

In many neurological disorders that disrupt spinal function and compromise breathing (eg
ALS, cervical spinal injury, MS), patients often maintain ventilatory capacity well after the …

The capability of the central nervous system to remyelinate axons after a lesion has been
well documented, even though it had been described as an abortive and incomplete …

Intraretinal myelination of ganglion cell axons occurs in about 1% of humans and when
observed ophthalmoscopically, appears as a white or opaque patch within the fiber layer …

Purpose: Human intraretinal myelination of ganglion cell axons occurs in about 1% of the
population. We examined myelin thickness and axon diameter in human retinal specimens …