The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …

Alterations in the regulation of gene expression are frequently associated with
developmental diseases or cancer. Transcription activation is a key phenomenon in the …

Abstract RNA polymerase II (Pol II) transcribes all protein-coding genes and many
noncoding RNAs in eukaryotic genomes. Although Pol II is a complex, 12-subunit enzyme, it …

Abstract The RNA polymerase II (Pol II) enzyme transcribes all protein-coding and most non-
coding RNA genes and is globally regulated by Mediator—a large, conformationally flexible …

Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …

Mediator is a conserved coactivator complex that enables the regulated initiation of
transcription at eukaryotic genes,–. Mediator is recruited by transcriptional activators and …

A common need for microbial cells is the ability to respond to potentially toxic environmental
insults. Here we review the progress in understanding the response of the yeast …

Uterine leiomyomas, or fibroids, are benign tumors that affect millions of women worldwide
and that can cause considerable morbidity. To study the genetic basis of this tumor type, we …

The Mediator is an evolutionarily conserved, multiprotein complex that is a key regulator of
protein-coding genes. In metazoan cells, multiple pathways that are responsible for …

The conserved co-activator complex Mediator enables regulated transcription initiation by
RNA polymerase (Pol) II. Here we reconstitute an active 15-subunit core Mediator (cMed) …