Over 1.66 million humans (approx. 500/100 000 population rate) and over 4.2 million dogs
(approx. 5300/100 000 population rate) are diagnosed with cancer annually in the USA. The …

Cancer is a common problem in dogs and although all breeds of dog and crossbred dogs
may be affected, it is notable that some breeds of pedigree dogs appear to be at increased …

Histiocytic proliferative disorders are commonly observed in dogs and less often cats.
Histiocytic disorders occur in most of the dendritic cell (DC) lineages. Canine cutaneous …

Spontaneous cancers in client-owned dogs closely recapitulate their human counterparts
with respect to clinical presentation, histological features, molecular profiles, and response …

Dogs are the most phenotypically diverse mammalian species, and they possess more
known heritable disorders than any other non-human mammal. Efforts to catalog and …

In recent years Canis familiaris, the domestic dog, has drawn considerable attention as a
system in which to investigate the genetics of disease susceptibility, morphology and …

Domestic dogs are unique from other animal models of cancer in that they generally
experience spontaneous disease. In addition, most types of cancer observed in humans are …

Background Histiocytic malignancies in both humans and dogs are rare and poorly
understood. While canine histiocytic sarcoma (HS) is uncommon in the general domestic …

Histiocytic sarcoma (HS) is a rare but aggressive cancer in both humans and dogs. The
spontaneous canine model, which has clinical, epidemiological, and histological similarities …

Background: Advantages offered by canine population substructure, combined with clinical
presentations similar to human disorders, makes the dog an attractive system for studies of …