A molecular view of DNA flexibility
DNA dynamics can only be understood by taking into account its complex mechanical
behavior at different length scales. At the micrometer level, the mechanical properties of …
behavior at different length scales. At the micrometer level, the mechanical properties of …
From Nucleosomes to Compartments: Physicochemical Interactions Underlying Chromatin Organization
Chromatin organization plays a critical role in cellular function by regulating access to
genetic information. However, understanding chromatin folding is challenging due to its …
genetic information. However, understanding chromatin folding is challenging due to its …
Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the
membraneless compartmentalization of the nucleus. Because chromatin compaction and …
membraneless compartmentalization of the nucleus. Because chromatin compaction and …
[HTML][HTML] Multiscale modeling of genome organization with maximum entropy optimization
ABSTRACT Three-dimensional (3D) organization of the human genome plays an essential
role in all DNA-templated processes, including gene transcription, gene regulation, and …
role in all DNA-templated processes, including gene transcription, gene regulation, and …
Determining sequence-dependent DNA oligonucleotide hybridization and dehybridization mechanisms using coarse-grained molecular simulation, markov state …
A robust understanding of the sequence-dependent thermodynamics of DNA hybridization
has enabled rapid advances in DNA nanotechnology. A fundamental understanding of the …
has enabled rapid advances in DNA nanotechnology. A fundamental understanding of the …
PICH acts as a force-dependent nucleosome remodeler
D Spakman, TVM Clement, AS Biebricher… - Nature …, 2022 - nature.com
In anaphase, any unresolved DNA entanglements between the segregating sister
chromatids can give rise to chromatin bridges. To prevent genome instability, chromatin …
chromatids can give rise to chromatin bridges. To prevent genome instability, chromatin …
DNA sliding in nucleosomes via twist defect propagation revealed by molecular simulations
While nucleosomes are highly stable structures as fundamental units of chromatin, they also
slide along the DNA, either spontaneously or by active remodelers. Here, we investigate the …
slide along the DNA, either spontaneously or by active remodelers. Here, we investigate the …
In silico evidence for sequence-dependent nucleosome sliding
J Lequieu, DC Schwartz… - Proceedings of the …, 2017 - National Acad Sciences
Nucleosomes represent the basic building block of chromatin and provide an important
mechanism by which cellular processes are controlled. The locations of nucleosomes …
mechanism by which cellular processes are controlled. The locations of nucleosomes …
Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin
Polycomb repressive complex 2 (PRC2) installs and spreads repressive histone methylation
marks on eukaryotic chromosomes. Because of the key roles that PRC2 plays in …
marks on eukaryotic chromosomes. Because of the key roles that PRC2 plays in …
Spatial and temporal organization of chromatin at small and large scales
H Schiessel - Annual Review of Condensed Matter Physics, 2023 - annualreviews.org
DNA molecules with a total length of two meters contain the genetic information in every cell
in our body. To control access to the genes, to organize its spatial structure in the nucleus …
in our body. To control access to the genes, to organize its spatial structure in the nucleus …