Whole transcriptome analysis plays an essential role in deciphering genome structure and
function, identifying genetic networks underlying cellular, physiological, biochemical and …

Prostate cancer is among the most common malignancies. It is estimated that 1 in 6 men in
the United States will be diagnosed with this disease. Despite the high prevalence and …

Purpose Persistence of ligand-mediated androgen receptor signaling has been documented
in castration-resistant prostate cancers (CRPCs). Abiraterone acetate (AA) is a potent and …

The human prostate gland is an important target organ of androgenic hormones.
Testosterone and dihydrotestosterone interact with the androgen receptor to regulate vital …

Proteomics research requires methods to characterize the expression and function of
proteins in complex mixtures. Toward this end, chemical probes that incorporate known …

Prostate cancer is an increasing threat throughout the world. As a result of a demographic
shift in population, the number of men at risk for developing prostate cancer is growing …

Consistent with both the development of the normal prostate gland and prostate
tumorigenesis being dependent on testicular androgens, targeting the androgen-signaling …

With complete genome sequences now available for several prokaryotic and eukaryotic
organisms, biological researchers are charged with the task of assigning molecular and …

2D gel electrophoresis is the technology that everyone loves to hate—it requires manual
dexterity and precision to reproduce precisely and is thus not well-suited as a high …

Multiple, complex molecular events characterize cancer development and progression.
Deciphering the molecular networks that distinguish organ-confined disease from metastatic …