Evolution in medicinal chemistry of sorafenib derivatives for hepatocellular carcinoma
F Chen, Y Fang, R Zhao, J Le, B Zhang… - European Journal of …, 2019 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Traditional
chemotherapy drugs are hard to reach a satisfactory therapeutic effect since advanced HCC …
chemotherapy drugs are hard to reach a satisfactory therapeutic effect since advanced HCC …
Synthesis, antitumor, and apoptosis-inducing activities of novel 5-arylidenethiazolidine-2, 4-dione derivatives: histone deacetylases inhibitory activity and molecular …
The antitumor activity of the newly synthesized 5-arylidenethiazolidine-2, 4-dione derivatives
18a–f and 19a–f was investigated, compared to doxorubicin (IC 50= 4.17–8.87 μM) and …
18a–f and 19a–f was investigated, compared to doxorubicin (IC 50= 4.17–8.87 μM) and …
A Review on the Chemistry of Nicotinonitriles and Their applications
AH Shamroukh, ER Kotb, MM Anwar… - Egyptian Journal of …, 2021 - journals.ekb.eg
Several studies on nicotinonitrile and their derivatives because of their wide range of
therapeutic activities have been reported. Many drugs containing nicotinonitrile derivatives …
therapeutic activities have been reported. Many drugs containing nicotinonitrile derivatives …
Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer
EA Abdelsalam, AA Abd El-Hafeez… - Journal of enzyme …, 2022 - Taylor & Francis
New series of thiazolyl-pyrazoline derivatives (7a–7d, 10a–10d and 13a–13f) have been
synthesised and assessed for their potential EGFR and VEGFR-2 inhibitory activities …
synthesised and assessed for their potential EGFR and VEGFR-2 inhibitory activities …
Novel 4-(2-arylidenehydrazineyl) thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico …
HA Elsebaie, EA El-Bastawissy, KM Elberembally… - Bioorganic …, 2023 - Elsevier
The current study discovered fifteen new thieno [2, 3-d] pyrimidine derivatives with potential
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …
Design, synthesis, and antitumor activity of novel compounds based on 1, 2, 4-triazolophthalazine scaffold: apoptosis-inductive and PCAF-inhibitory effects
The antitumor activity of newly synthesised triazolophthalazines (L-45 analogues) 10–32
was evaluated in human hepatocellular carcinoma (HePG-2), breast cancer (MCF-7) …
was evaluated in human hepatocellular carcinoma (HePG-2), breast cancer (MCF-7) …
Design, synthesis, antitumor, and VEGFR-2 inhibition activities of novel 4-anilino-2-vinyl-quinazolines: Molecular modeling studies
The antitumor activity of newly synthesized 4-anilino-2-vinylquinazolines 8a-r was measured
comparable to sorafenib as a standard drug. The 2-vinylquinazolines 8a-r were evaluated …
comparable to sorafenib as a standard drug. The 2-vinylquinazolines 8a-r were evaluated …
[HTML][HTML] Bioactive compounds, antioxidant capacity and antitumoral activity of ethanolic extracts from fruits and seeds of Eugenia involucrata DC
JR Girardelo, EL Munari, JCS Dallorsoleta… - Food Research …, 2020 - Elsevier
Eugenia involucrata DC.(Myrtaceae) is a native tree species from Brazil that has been
scarcely studied. We investigated the phenolic composition, the antioxidant capacity and the …
scarcely studied. We investigated the phenolic composition, the antioxidant capacity and the …
[HTML][HTML] Synthesis, anticancer, apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 5, 5-diphenylimidazolidine-2, 4-dione derivatives …
HM Alkahtani, MM Alanazi, FS Aleanizy… - Saudi Pharmaceutical …, 2019 - Elsevier
Abstract A new series of 5, 5-diphenylhydantoin derivatives containing benzylidene or isatin
(4–19) was synthesized. Their anticancer activity against HeLa, a cervical cancer cell line …
(4–19) was synthesized. Their anticancer activity against HeLa, a cervical cancer cell line …
Design, synthesis and docking studies of novel macrocyclic pentapeptides as anticancer multi-targeted kinase inhibitors
AEGE Amr, MH Abo-Ghalia, GO Moustafa, MA Al-Omar… - Molecules, 2018 - mdpi.com
A series of macrocyclic pyrido-pentapeptide candidates 2–6 were synthesized by using N, N-
bis-[1-carboxy-2-(benzyl)]-2, 6-(diaminocarbonyl) pyridine 1a, b as starting material …
bis-[1-carboxy-2-(benzyl)]-2, 6-(diaminocarbonyl) pyridine 1a, b as starting material …