Background: Metastasis is the primary cause of death in most human cancers, and
understanding the molecular mechanisms underpinning this multistep process is …

Src homology 2 (SH2) domains are 100 amino acid modular units, which recognize and
bind to tyrosyl-phosphorylated peptide sequences on their target proteins, and thereby …

Positron emission tomography (PET) plays key roles in drug discovery and development, as
well as medical imaging. However, there is a dearth of efficient and simple radiolabeling …

Currently, FLT3 tyrosine kinase inhibitors (TKIs) are emerging as the most promising drug
therapy to overcome the dismal prognosis of acute myelogenous leukemia (AML) patients …

Background: Growth factor receptor-bound protein 2 (Grb2) is a 25 kDa adaptor protein,
which was originally discovered to accomplish basic cellular events such as cell growth, cell …

We identified 1219 articles published in 2006 that described work performed using
commercial optical biosensor platforms. It is interesting to witness how the biosensor market …

Background The role of the membrane-associated RING-CH (MARCH) family in
carcinogenesis has been widely studied, but the member of this family, RNF173, has not yet …

Background Necroptosis and pyroptosis, two types of proinflammatory programmed cell
death, were recently found to play important roles in spinal cord injury (SCI). Moreover …

Neuroprotective agents with attenuation of oxidative stress by directly scavenging ROS and
indirectly through Keap1-Nrf2 signal pathway activation may be a promising cerebral …

Helix B surface peptide (HBSP), derived from erythropoietin, displays powerful tissue
protection during kidney ischemia reperfusion (IR) injury without erythropoietic side effects …