Proteases have an important role in many signalling pathways, and represent potential drug
targets for diseases ranging from cardiovascular disorders to cancer, as well as for …

Serine hydrolases perform crucial roles in many biological processes, and several of these
enzymes are targets of approved drugs for indications such as type 2 diabetes, Alzheimer's …

Over the last two decades, a novel subgroup of serine proteases, the cell surface–anchored
serine proteases, has emerged as an important component of the human degradome, and …

Serine proteases of the trypsin-like family have long been recognized to be critical effectors
of biological processes as diverse as digestion, blood coagulation, fibrinolysis, and …

Pericellular proteases have long been implicated in carcinogenesis. Previous research
focused on these proteins, primarily as extracellular matrix (ECM) protein‐degrading …

TMPRSS4 is a novel type II transmembrane serine protease found at the cell surface that is
highly expressed in pancreatic, colon and gastric cancer tissues. However, the biological …

Pericellular proteolysis provides a significant advantage to developing tumors through the
ability to remodel the extracellular matrix, promote cell invasion and migration, and facilitate …

We identified 1219 articles published in 2006 that described work performed using
commercial optical biosensor platforms. It is interesting to witness how the biosensor market …

Cell membrane‐bound serine proteases are important in the maintenance of physiological
homeostasis. Hepsin is a type II transmembrane serine protease highly expressed in the …

Hepsin, a cell surface protease, is widely reported to be overexpressed in more than 90% of
human prostate tumors. Hepsin expression correlates with tumor progression, making it a …