Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

Immune tolerance is necessary to prevent the immune system from reacting against self, and
thus to avoid the development of autoimmune diseases. In this review, we discuss key …

The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic
transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets …

Inborn errors of human interferon gamma (IFN-γ) immunity underlie mycobacterial disease.
We report a patient with mycobacterial disease due to inherited deficiency of the …

IRF8 and IRF1 are transcriptional regulators that play critical roles in the development and
function of myeloid cells, including activation of macrophages by proinflammatory signals …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb) and a few related
mycobacteria, is a devastating disease, killing more than a million individuals per year …

A key aspect of TB pathogenesis that maintains Mycobacterium tuberculosis in the human
population is the ability to cause necrosis in pulmonary lesions. As co-evolution shaped M …

The transcription factor IRF8 (ICSBP) is required for the development and maturation of
myeloid cells (dendritic cells, monocytes, macrophages), and for expression of intrinsic anti …

Cancer and the immune system are intimately related. Much of the bulk of tumors is
comprised of stromal leukocytes with immune functions, which serve to both promote and …