Mitophagy mediated by the recessive Parkinson's disease genes PINK1 and Parkin
responds to mitochondrial damage to preserve mitochondrial function. In the pathway …

Parkinson's disease (PD) is the second most common neurodegenerative disease and
represents a looming public health crisis as the global population ages. While the etiology of …

Mutations in parkin and PINK1 cause early-onset Parkinson's disease (EOPD). The ubiquitin
ligase parkin is recruited to damaged mitochondria and activated by PINK1, a kinase that …

There has been long-term interest in drugging the PINK1-Parkin pathway with therapeutics
as a treatment for Parkinson's disease (PD). Despite significant structural data on Parkin as …

Parkinson's disease is a neurodegenerative disorder characterised by cardinal motor
symptoms and a diverse range of non-motor disorders in patients. Parkinson's disease is the …

Proteostasis can be disturbed by mutations affecting folding and stability of the encoded
protein. An example is the ubiquitin ligase Parkin, where gene variants result in autosomal …

Arrestins were discovered for their role in homologous desensitization of G‐protein‐coupled
receptors (GPCRs). Later non‐visual arrestins were shown to regulate several signaling …

The pathogenesis of Parkinson's disease (PD) has been associated with mitochondrial
dysfunction. Given that the PINK1/Parkin pathway governs mitochondrial quality control by …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder.
There are no available therapeutics that slow or halt the progressive loss of dopamine …

Parkinson's disease (PD) is a progressive neurological disorder that manifests clinically as
alterations in movement as well as multiple non-motor symptoms including but not limited to …