LncRNA MALAT1 signaling pathway and clinical applications in overcome on cancers metastasis
M Mazarei, V Shahabi Rabori, N Ghasemi… - Clinical and …, 2023 - Springer
In spite of its high mortality rate and difficulty in finding a cure, scientific advancements have
contributed to a reduction in cancer-related fatalities. Aberrant gene expression during …
contributed to a reduction in cancer-related fatalities. Aberrant gene expression during …
Modeling of spatiotemporal dynamics of ligand-coated particle flow in targeted drug delivery processes
Nanoparticles tethered with vasculature-binding epitopes have been used to deliver the
drug into injured or diseased tissues via the bloodstream. However, the extent that blood …
drug into injured or diseased tissues via the bloodstream. However, the extent that blood …
3D vascularized microphysiological system for investigation of tumor-endothelial crosstalk in anti-cancer drug resistance
Despite the advantages of microfluidic system in drug screening, vascular systems
responsible for the transport of drugs and nutrients have been hardly considered in the …
responsible for the transport of drugs and nutrients have been hardly considered in the …
[HTML][HTML] Vascularized tumor models for the evaluation of drug delivery systems: a paradigm shift
As the conversion rate of preclinical studies for cancer treatment is low, user-friendly models
that mimic the pathological microenvironment and drug intake with high throughput are …
that mimic the pathological microenvironment and drug intake with high throughput are …
Engineering microvascular networks using a KLF2 reporter to probe flow-dependent endothelial cell function
Shear stress generated by the flow of blood in the vasculature is a potent regulator of
endothelial cell function and vascular structure. While vascular responses to flow are …
endothelial cell function and vascular structure. While vascular responses to flow are …
[HTML][HTML] Interaction of drug-sensitive and-resistant human melanoma cells with HUVEC cells: A label-free cell-based impedance study
G Bozzuto, M Colone, L Toccacieli, A Molinari… - Biomedicines, 2023 - mdpi.com
Cancer cell extravasation is a crucial step in cancer metastasis. However, many of the
mechanisms involved in this process are only now being elucidated. Thus, in the present …
mechanisms involved in this process are only now being elucidated. Thus, in the present …
A Versatile Microfluidic Platform for Extravasation Studies Based on DNA Origami—Cell Interactions
M García‐Chamé, P Wadhwani, J Pfeifer… - Angewandte …, 2024 - Wiley Online Library
The adhesion of circulating tumor cells (CTCs) to the endothelial lumen and their
extravasation to surrounding tissues are crucial in the seeding of metastases and remain the …
extravasation to surrounding tissues are crucial in the seeding of metastases and remain the …
[HTML][HTML] Hydrophobic surface induced pro-metastatic cancer cells for in vitro extravasation models
In vitro vascularized cancer models utilizing microfluidics have emerged as a promising tool
for mechanism study and drug screening. However, the lack of consideration and …
for mechanism study and drug screening. However, the lack of consideration and …
The Mechanism of Tumor Metastasis
G Qu - Highlights in Science, Engineering and Technology, 2023 - drpress.org
Nowadays, cancer is the leading cause of human health problems, and the vast majority of
deaths are caused by metastatic cancer. The disease is not easy to detect in the early stage …
deaths are caused by metastatic cancer. The disease is not easy to detect in the early stage …