Structural insights into SARS-CoV-2 proteins

R Arya, S Kumari, B Pandey, H Mistry, SC Bihani… - Journal of molecular …, 2021 - Elsevier
The unprecedented scale of the ongoing COVID-19 pandemic has catalyzed an intense
effort of the global scientific community to unravel different aspects of the disease in a short …

Emerging coronaviruses: genome structure, replication, and pathogenesis

Y Chen, Q Liu, D Guo - Journal of medical virology, 2020 - Wiley Online Library
The recent emergence of a novel coronavirus (2019‐nCoV), which is causing an outbreak of
unusual viral pneumonia in patients in Wuhan, a central city in China, is another warning of …

[HTML][HTML] The molecular virology of coronaviruses

E Hartenian, D Nandakumar, A Lari, M Ly… - Journal of Biological …, 2020 - ASBMB
Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

W Yin, C Mao, X Luan, DD Shen, Q Shen, H Su… - Science, 2020 - science.org
The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has become a global crisis. Replication of SARS …

[HTML][HTML] Coronavirus RNA proofreading: molecular basis and therapeutic targeting

F Robson, KS Khan, TK Le, C Paris, S Demirbag… - Molecular cell, 2020 - cell.com
Summary The coronavirus disease 2019 (COVID-19) that is wreaking havoc on worldwide
public health and economies has heightened awareness about the lack of effective antiviral …

[HTML][HTML] Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

A Shannon, B Selisko, NTT Le, J Huchting… - Nature …, 2020 - nature.com
Abstract The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need …

Two years into the COVID-19 pandemic: lessons learned

SJR da Silva, JCF do Nascimento… - ACS infectious …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …

Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme

C Liu, W Shi, ST Becker, DG Schatz, B Liu, Y Yang - Science, 2021 - science.org
Coronavirus 3′-to-5′ exoribonuclease (ExoN), residing in the nonstructural protein (nsp)
10–nsp14 complex, boosts replication fidelity by proofreading RNA synthesis and is critical …

[HTML][HTML] The SARS-coronavirus infection cycle: a survey of viral membrane proteins, their functional interactions and pathogenesis

NA Wong, MH Saier Jr - International journal of molecular sciences, 2021 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a novel epidemic
strain of Betacoronavirus that is responsible for the current viral pandemic, coronavirus …

The nonstructural proteins directing coronavirus RNA synthesis and processing

EJ Snijder, E Decroly, J Ziebuhr - Advances in virus research, 2016 - Elsevier
Coronaviruses are animal and human pathogens that can cause lethal zoonotic infections
like SARS and MERS. They have polycistronic plus-stranded RNA genomes and belong to …