Understanding asthma phenotypes, endotypes, and mechanisms of disease
ME Kuruvilla, FEH Lee, GB Lee - Clinical reviews in allergy & immunology, 2019 - Springer
The model of asthma as a single entity has now been replaced by a much more complex
biological network of distinct and interrelating inflammatory pathways. The term asthma is …
biological network of distinct and interrelating inflammatory pathways. The term asthma is …
[HTML][HTML] The cytokines of asthma
BN Lambrecht, H Hammad, JV Fahy - Immunity, 2019 - cell.com
Asthma is a chronic inflammatory airway disease associated with type 2 cytokines
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus …
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus …
Mast cells as sources of cytokines, chemokines, and growth factors
Mast cells are hematopoietic cells that reside in virtually all vascularized tissues and that
represent potential sources of a wide variety of biologically active secreted products …
represent potential sources of a wide variety of biologically active secreted products …
Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma
CD4+ T helper (TH) cells and regulatory T (Treg) cells that respond to common allergens
play an important role in driving and dampening airway inflammation in patients with …
play an important role in driving and dampening airway inflammation in patients with …
Treatment options in type-2 low asthma
TSC Hinks, SJ Levine… - European Respiratory …, 2021 - Eur Respiratory Soc
Monoclonal antibodies targeting IgE or the type-2 cytokines interleukin (IL)-4, IL-5 and IL-13
are proving highly effective in reducing exacerbations and symptoms in people with severe …
are proving highly effective in reducing exacerbations and symptoms in people with severe …
T2-“low” asthma: overview and management strategies
AM Fitzpatrick, BE Chipps, F Holguin… - The Journal of Allergy and …, 2020 - Elsevier
Although the term “asthma” has been applied to all patients with airway lability and variable
chest symptoms for centuries, phenotypes of asthma with distinct clinical and molecular …
chest symptoms for centuries, phenotypes of asthma with distinct clinical and molecular …
Expression of SARS-CoV-2 receptor ACE2 and coincident host response signature varies by asthma inflammatory phenotype
Background More than 300 million people carry a diagnosis of asthma, with data to suggest
that they are at a higher risk for infection or adverse outcomes from severe acute respiratory …
that they are at a higher risk for infection or adverse outcomes from severe acute respiratory …
CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma
M Gauthier, SL Kale, TB Oriss, M Gorry… - Journal of Allergy and …, 2023 - Elsevier
Background Type 1 (T1) inflammation (marked by IFN-γ expression) is now consistently
identified in subsets of asthma cohorts, but how it contributes to disease remains unclear …
identified in subsets of asthma cohorts, but how it contributes to disease remains unclear …
[HTML][HTML] Determining asthma endotypes and outcomes: Complementing existing clinical practice with modern machine learning
There is unprecedented opportunity to use machine learning to integrate high-dimensional
molecular data with clinical characteristics to accurately diagnose and manage disease …
molecular data with clinical characteristics to accurately diagnose and manage disease …
Are we meeting the promise of endotypes and precision medicine in asthma?
While the term asthma has long been known to describe heterogeneous groupings of
patients, only recently have data evolved which enable a molecular understanding of the …
patients, only recently have data evolved which enable a molecular understanding of the …