Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

Rapid removal of glutamate from the extracellular space is required for the survival and
normal function of neurons. Although glutamate transporters are expressed by all CNS cell …

l-Glutamate is the predominant excitatory neurotransmitter in the mammalian central
nervous system and plays important roles in a wide variety of brain functions, but it is also a …

Glutamate transporters are integral membrane proteins that catalyse the concentrative
uptake of glutamate from the synapse to intracellular spaces by harnessing pre-existing ion …

Glutamate transporters play important roles in the termination of excitatory
neurotransmission and in providing cells throughout the body with glutamate for metabolic …

Secondary transporters are integral membrane proteins that catalyse the movement of
substrate molecules across the lipid bilayer by coupling substrate transport to one or more …

The solute carrier family 1 (SLC1) includes five high-affinity glutamate transporters, EAAC1,
GLT-1, GLAST, EAAT4 and EAAT5 (SLC1A1, SLC1A2, SLC1A3, SLC1A6, and SLC1A7 …

The solute carrier family 1 (SLC1) is composed of five high affinity glutamate transporters,
which exhibit the properties of the previously described system XAG−, as well as two Na+ …

Historically, glutamate uptake in the CNS was mainly attributed to glial cells for three
reasons: 1) none of the glutamate transporters were found to be located in presynaptic …

Glutamate transporters remove the excitatory neurotransmitter glutamate from the
extracellular space after neurotransmission is complete, by taking glutamate up into neurons …