The proteins of the mammalian neurotrophin family (nerve growth factor (NGF), brain-
derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5)) …

Regulated exocytosis of secretory granules or dense-core granules has been examined in
many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …

Generation, Control, and Processing of Cellular Calcium Signals Page 1 107 1040-9238/01/$.50
© 2001 by CRC Press LLC Critical Reviews in Biochemistry and Molecular Biology, 36(2):107–260 …

Calcium ions play crucial signaling roles in many forms of activity-dependent synaptic
plasticity. Recent presynaptic [Ca2+] i measurements and manipulation of presynaptic …

Synaptic vesicles release neurotransmitter at chemical synapses, thus initiating the flow of
information in neural networks. To achieve this, vesicles undergo a dynamic cycle of fusion …

Hearing in mammals relies on the highly synchronous synaptic transfer between cochlear
inner hair cells (IHCs) and the auditory nerve. We studied the presynaptic function of single …

At a given cytosolic domain of a chromaffin cell, the rate and amplitude of the Ca2+
concentration ([Ca2+] c) depends on at least four efficient regulatory systems: 1) …

Presynaptic short-term plasticity is an important adaptive mechanism regulating synaptic
transmitter release at varying action potential frequencies. However, the underlying …

The SNARE complex, consisting of synaptobrevin, syntaxin, and SNAP-25, is essential for
calcium-triggered exocytosis in neurosecretory cells. Little is known, however, about how …

We have identified and characterized two vesicle recycling pathways in frog motor nerve
terminals. We exploited the differential staining properties of FM dyes of varying …