Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …
century. It is a well-recognized multifactorial health problem contributes significantly to high …
Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis, in vitro biological evaluation, and in silico ADMET analysis with …
Recently, scientists developed a powerful strategy called “one drug-multiple targets” to
discover vital and unique therapies to fight the most challenging diseases. Novel derivatives …
discover vital and unique therapies to fight the most challenging diseases. Novel derivatives …
Isatin conjugates as antibacterial agents: a brief review
Pathogenic bacteria, with their innate resistance to drugs, pose a constant threat to human
health and well-being and put a persistent strain on the health care system. Development of …
health and well-being and put a persistent strain on the health care system. Development of …
Arylureidoaurones: Synthesis, in vitro α-glucosidase, and α-amylase inhibition activity
M Kazempour-Dizaji, S Mojtabavi, A Sadri… - Bioorganic …, 2023 - Elsevier
Because of the colossal global burden of diabetes, there is an urgent need for more effective
and safer drugs. We designed and synthesized a new series of aurone derivatives …
and safer drugs. We designed and synthesized a new series of aurone derivatives …
Design, synthesis, and in silico studies of quinoline-based-benzo [d] imidazole bearing different acetamide derivatives as potent α-glucosidase inhibitors
M Noori, A Davoodi, A Iraji, N Dastyafteh, M Khalili… - Scientific Reports, 2022 - nature.com
In this study, 18 novel quinoline-based-benzo [d] imidazole derivatives were synthesized
and screened for their α-glucosidase inhibitory potential. All compounds in the series except …
and screened for their α-glucosidase inhibitory potential. All compounds in the series except …
Synthesis, antimicrobial, antibiofilm and computational studies of isatin-semicarbazone tethered 1, 2, 3-triazoles
In present era, heterocyclic compounds containing two or three nitrogen atoms play a vital
role in drug discovery. In this context, a new class of isatin-semicarbazone tethered 1, 2, 3 …
role in drug discovery. In this context, a new class of isatin-semicarbazone tethered 1, 2, 3 …
Phenoxy pendant isatins as potent α-glucosidase inhibitors: reciprocal carbonyl⋯ carbonyl interactions, antiparallel π⋯ π stacking driven solid state self-assembly and …
Carbonyl–carbonyl (CO⋯ CO) interactions are recently explored noncovalent interactions of
significant interest owing to their role in the stability of biomacromolecules. Currently …
significant interest owing to their role in the stability of biomacromolecules. Currently …
Synthesis, vibrational spectra, Hirshfeld surface analysis, DFT calculations, and in silico ADMET study of 3-(2-chloroethyl)-2, 6-bis (4-fluorophenyl) piperidin-4-one: a …
A Ramalingam, AR Guerroudj, S Sambandam… - Journal of Molecular …, 2022 - Elsevier
This study included experimental analysis, FT-Raman, FT-IR, UV-Vis and NMR with
theoretical investigations of 3-(2-chloroethyl)-2, 6-bis (p-fluorophenyl) piperidin-4-one …
theoretical investigations of 3-(2-chloroethyl)-2, 6-bis (p-fluorophenyl) piperidin-4-one …
Synthesis of 3‐hydroxy‐2‐naphthohydrazide‐based hydrazones and their implications in diabetic management via in vitro and in silico approaches
Diabetes mellitus (DM) has prevailed as a chronic health condition and has become a
serious global health issue due to its numerous consequences and high prevalence. We …
serious global health issue due to its numerous consequences and high prevalence. We …
Novel N′-substituted benzylidene benzohydrazides linked to 1,2,3-triazoles: potent α-glucosidase inhibitors
Herein, various N′-substituted benzylidene benzohydrazide-1, 2, 3-triazoles were
designed, synthesized, and screened for their inhibitory activity toward α-glucosidase. The …
designed, synthesized, and screened for their inhibitory activity toward α-glucosidase. The …