Yellow fever (YF) was one of the most dangerous infectious diseases of the 18th and 19th
centuries, resulting in mass casualties in Africa and the Americas. The etiologic agent is …

Vaccination is the most effective method of disease prevention and control. Many viruses
and bacteria that once caused catastrophic pandemics (eg, smallpox, poliomyelitis …

BACKGROUND Typhoid fever is caused by the Gram-negative bacterium Salmonella
enterica serovar Typhi and poses a substantial public health burden worldwide. Vaccines …

Abstract SARS-CoV-2 wastewater-based surveillance (WBS) offers a tool for cost-effective
oversight of a population's infections. In the past two years, WBS has proven to be crucial for …

Ebola virus disease is a severe hemorrhagic fever with a high fatality rate. We investigate
transcriptome profiles at 3 h, 1 day, and 7 days after vaccination with Ad26. ZEBOV and MVA …

Understanding the mechanisms of vaccine-elicited protection contributes to the
development of new vaccines. The emerging field of systems vaccinology provides detailed …

Burkholderia pseudomallei is a Gram-negative, facultative intracellular bacillus that causes
the disease melioidosis. B. pseudomallei expresses a number of proteins that contribute to …

Zika Virus (ZIKV) and Dengue Virus (DENV) are related viruses of the Flavivirus genus that
cause significant disease in humans. Existing control measures have been ineffective at …

Individuals vary broadly in their response to vaccination and subsequent challenge
infection, with poor vaccine responders causing persistence of both infection and …

Vaccines are among the most cost-effective public health interventions for preventing
infection-induced morbidity and mortality, yet much remains to be learned regarding the …