APT‐weighted MRI: techniques, current neuro applications, and challenging issues

J Zhou, HY Heo, L Knutsson… - Journal of Magnetic …, 2019 - Wiley Online Library
Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that
generates image contrast based predominantly on the amide protons in mobile cellular …

Clinical applications of chemical exchange saturation transfer (CEST) MRI

KM Jones, AC Pollard, MD Pagel - Journal of Magnetic …, 2018 - Wiley Online Library
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has
been developed and employed in multiple clinical imaging research centers worldwide …

Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging

O Ciccarelli, F Barkhof, B Bodini, N De Stefano… - The Lancet …, 2014 - thelancet.com
The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that
underpin relapse-associated and progressive disability. Disease mechanisms can be …

CEST: from basic principles to applications, challenges and opportunities

E Vinogradov, AD Sherry, RE Lenkinski - Journal of magnetic resonance, 2013 - Elsevier
Chemical Exchange Saturation Transfer (CEST) offers a new type of contrast for MRI that is
molecule specific. In this approach, a slowly exchanging NMR active nucleus, typically a …

Three‐dimensional amide proton transfer MR imaging of gliomas: initial experience and comparison with gadolinium enhancement

J Zhou, H Zhu, M Lim, L Blair… - Journal of Magnetic …, 2013 - Wiley Online Library
Purpose To investigate the feasibility of a three‐dimensional amide‐proton‐transfer (APT)
imaging sequence with gradient‐and spin‐echo readouts at 3 Tesla in patients with high‐or …

Chemical exchange saturation transfer (CEST) imaging: description of technique and potential clinical applications

F Kogan, H Hariharan, R Reddy - Current radiology reports, 2013 - Springer
Chemical exchange saturation transfer (CEST) is a magnetic resonance imaging (MRI)
contrast enhancement technique that enables indirect detection of metabolites with …

In vivo three‐dimensional whole‐brain pulsed steady‐state chemical exchange saturation transfer at 7 T

CK Jones, D Polders, J Hua, H Zhu… - Magnetic resonance …, 2012 - Wiley Online Library
Chemical exchange saturation transfer (CEST) is a technique to indirectly detect pools of
exchangeable protons through the water signal. To increase its applicability to human …

Review and consensus recommendations on clinical APT‐weighted imaging approaches at 3T: application to brain tumors

J Zhou, M Zaiss, L Knutsson, PZ Sun… - Magnetic resonance …, 2022 - Wiley Online Library
Amide proton transfer‐weighted (APTw) MR imaging shows promise as a biomarker of brain
tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially …

Snapshot‐CEST: optimizing spiral‐centric‐reordered gradient echo acquisition for fast and robust 3D CEST MRI at 9.4 T

M Zaiss, P Ehses, K Scheffler - NMR in Biomedicine, 2018 - Wiley Online Library
Gradient echo (GRE)‐based acquisition provides a robust readout method for chemical
exchange saturation transfer (CEST) at ultrahigh field (UHF). To develop a snapshot‐CEST …

On the origins of chemical exchange saturation transfer (CEST) contrast in tumors at 9.4 T

J Xu, M Zaiss, Z Zu, H Li, J Xie, DF Gochberg… - NMR in …, 2014 - Wiley Online Library
Chemical exchange saturation transfer (CEST) provides an indirect means to detect
exchangeable protons within tissues through their effects on the water signal. Previous …