Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

The recent expansion of multidrug resistant and pan-drug-resistant pathogens poses
significant challenges in the treatment of healthcare associated infections. An important …

abstract Galleria mellonella (greater wax moth or honeycomb moth) has been introduced as
an alternative model to study microbial infections. G. mellonella larvae can be easily and …

The larva of the greater wax moth Galleria mellonella is an increasingly popular model for
assessing the virulence of bacterial pathogens and the effectiveness of antimicrobial agents …

A literature review was undertaken to ascertain the molecular basis for tigecycline and
colistin resistance mechanisms and the experimental basis for the detection and delineation …

Introduction: Living in the 'era of antibiotic resistance'and facing the threat of an 'end to
antibiotics', physicians in the last decade have revived use of colistin, since the available …

The spread of carbapenem-non-susceptible Klebsiella pneumoniae strains bearing different
resistance determinants is a rising problem worldwide. Especially infections with KPC …

The widespread antimicrobial resistance (AMR) calls for the development of new
antimicrobial strategies. Antibiotic adjuvant rescues antibiotic activity and increases the life …

Introduction: The ongoing crisis and emergence of extensively-drug resistant (XDR) gram-
negative pathogens in the nosocomial setting is worrisome. The limited armamentarium in …

We investigated activities of cefiderocol combination therapy against carbapenem-resistant
Acinetobacter baumannii (CR-AB). A total of 123 clinical isolates of CR-AB, including 44 …