Drastic epigenetic reprogramming takes place during preimplantation development, leading
to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in …

BACKGROUND Despite advances in ART, implantation and pregnancy rates per embryo
transfer still remain low. IVF laboratories strive to ensure that the process of handling …

Genomic imprinting is a complex epigenetic process that contributes substantially to
embryogenesis, reproduction, and gametogenesis. Only small fraction of genes within the …

Mitochondria, originally of bacterial origin, are highly dynamic organelles that have evolved
a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage …

The developmental competence of in vitro cultured (IVC) embryos is markedly lower than
that of their in vivo counterparts, suggesting the need for optimization of IVC protocols …

Since the birth of Louise Brown in 1978 via IVF, reproductive specialists have acquired
enormous knowledge and refined several procedures, which are nowadays applied in …

Since the birth of Louise Joy Brown, the first baby conceived via in vitro fertilization, more
than 9 million children have been born worldwide using assisted reproductive technologies …

Throughout our lives, epigenetic processes shape our development and enable us to adapt
to a constantly changing environment. Identifying and understanding environmentally …

The optimum oxygen tension for culturing mammalian embryos has been widely debated by
the scientific community. While several laboratories have moved to using 5% as the value for …

Metabolism is central to embryonic stem cell (ESC) pluripotency and differentiation, with
distinct profiles apparent under different nutrient milieu, and conditions that maintain …