Chronic myeloid leukemia (CML) is probably the most extensively studied human
malignancy. The discovery of the Philadelphia (Ph) chromosome in 19601 as the first …

Eph receptors constitute the largest family of tyrosine kinase receptors and, together with
their plasma-membrane-bound ephrin ligands, have many important functions during …

When mammals fast, glucose homeostasis is achieved by triggering expression of
gluconeogenic genes in response to glucagon and glucocorticoids. The pathways act …

Abstract Members of the Wiskott–Aldrich syndrome protein (WASP) family control
cytoskeletal dynamics by promoting actin filament nucleation with the Arp2/3 complex. The …

Abstract The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA,
ecstasy) is a popular recreational drug among young people, particularly those involved in …

ABL-family proteins comprise one of the best conserved branches of the tyrosine kinases.
Each ABL protein contains an SH3-SH2-TK (Src homology 3–Src homology 2–tyrosine …

▪ Abstract The guidance of axons during the establishment of the nervous system is
mediated by a variety of extracellular cues that govern cytoskeletal dynamics in axonal …

The Rho GTPase Rac1 activates the WAVE regulatory complex (WRC) to drive Arp2/3
complex-mediated actin polymerization, which underpins diverse cellular processes. Here …

Abstract The Bcr-Abl fusion protein kinase causes chronic myeloid leukemia and is targeted
by the signal transduction inhibitor STI-571/Gleevec/imatinib (STI-571). Sequencing of the …

The Philadelphia chromosome translocation (t [9; 22]) results in the molecular juxtaposition
of two genes, BCR and ABL, to form an aberrant BCR-ABL gene on chromosome 22. BCR …