Summary The 2015 Magnetic Resonance Imaging in Multiple Sclerosis and 2016
Consortium of Multiple Sclerosis Centres guidelines on the use of MRI in diagnosis and …

The factor that is most relevant and strongly associated with the clinical course of multiple
sclerosis is chronological age. Very young patients exclusively have relapsing remitting …

Recent data suggest that multiple sclerosis white matter lesions surrounded by a rim of iron
containing microglia, termed iron rim lesions, signify patients with more severe disease …

Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Background and Objectives Chronic active lesions contribute to multiple sclerosis (MS)
severity, but their association with long-term disease progression has not been evaluated …

The rapidly evolving therapeutic landscape of multiple sclerosis (MS) has contributed to
paradigm shifts in our understanding of the biological mechanisms that contribute to CNS …

Objective To assess whether chronic white matter inflammation in patients with multiple
sclerosis (MS) as detected in vivo by paramagnetic rim MRI lesions (PRLs) is associated …

Chronic active lesions (CAL) are an important manifestation of chronic inflammation in
multiple sclerosis (MS) and have implications for non-relapsing biological progression. In …

The emphasis on mechanisms driving multiple sclerosis (MS) symptomatic worsening
suggests that we move beyond categorical clinical classifiers such as relapsing–remitting …

In recent years, the use of magnetic resonance imaging (MRI) for the diagnostic work-up of
multiple sclerosis (MS) has evolved considerably. The 2017 McDonald criteria show high …