Direct cell reprogramming: approaches, mechanisms and progress
The reprogramming of somatic cells with defined factors, which converts cells from one
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …
Epigenome editing technologies for discovery and medicine
Epigenome editing has rapidly evolved in recent years, with diverse applications that
include elucidating gene regulation mechanisms, annotating coding and noncoding …
include elucidating gene regulation mechanisms, annotating coding and noncoding …
Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases
CC Deng, YF Hu, DH Zhu, Q Cheng, JJ Gu… - Nature …, 2021 - nature.com
Fibrotic skin disease represents a major global healthcare burden, characterized by
fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts …
fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts …
A comprehensive library of human transcription factors for cell fate engineering
AHM Ng, P Khoshakhlagh, JE Rojo Arias… - Nature …, 2021 - nature.com
Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse
cell types and tissues. To enable systematic exploration of the programming landscape …
cell types and tissues. To enable systematic exploration of the programming landscape …
Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome
S Lago, M Nadai, FM Cernilogar, M Kazerani… - Nature …, 2021 - nature.com
Cell identity is maintained by activation of cell-specific gene programs, regulated by
epigenetic marks, transcription factors and chromatin organization. DNA G-quadruplex (G4) …
epigenetic marks, transcription factors and chromatin organization. DNA G-quadruplex (G4) …
Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer
Lineage plasticity, the ability of a cell to alter its identity, is an increasingly common
mechanism of adaptive resistance to targeted therapy in cancer. An archetypal example is …
mechanism of adaptive resistance to targeted therapy in cancer. An archetypal example is …
A predictive computational framework for direct reprogramming between human cell types
Transdifferentiation, the process of converting from one cell type to another without going
through a pluripotent state, has great promise for regenerative medicine. The identification of …
through a pluripotent state, has great promise for regenerative medicine. The identification of …
[HTML][HTML] CRISPR activation screens systematically identify factors that drive neuronal fate and reprogramming
Comprehensive identification of factors that can specify neuronal fate could provide valuable
insights into lineage specification and reprogramming, but systematic interrogation of …
insights into lineage specification and reprogramming, but systematic interrogation of …
Modeling gene regulation from paired expression and chromatin accessibility data
The rapid increase of genome-wide datasets on gene expression, chromatin states, and
transcription factor (TF) binding locations offers an exciting opportunity to interpret the …
transcription factor (TF) binding locations offers an exciting opportunity to interpret the …
Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization
A Kojic, A Cuadrado, M De Koninck… - Nature structural & …, 2018 - nature.com
Two variant cohesin complexes containing SMC1, SMC3, RAD21 and either SA1 (also
known as STAG1) or SA2 (also known as STAG2) are present in all cell types. We report …
known as STAG1) or SA2 (also known as STAG2) are present in all cell types. We report …