Direct cell reprogramming: approaches, mechanisms and progress

H Wang, Y Yang, J Liu, L Qian - Nature Reviews Molecular Cell Biology, 2021 - nature.com
The reprogramming of somatic cells with defined factors, which converts cells from one
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …

Epigenome editing technologies for discovery and medicine

SR McCutcheon, D Rohm, N Iglesias… - Nature …, 2024 - nature.com
Epigenome editing has rapidly evolved in recent years, with diverse applications that
include elucidating gene regulation mechanisms, annotating coding and noncoding …

Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

CC Deng, YF Hu, DH Zhu, Q Cheng, JJ Gu… - Nature …, 2021 - nature.com
Fibrotic skin disease represents a major global healthcare burden, characterized by
fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts …

A comprehensive library of human transcription factors for cell fate engineering

AHM Ng, P Khoshakhlagh, JE Rojo Arias… - Nature …, 2021 - nature.com
Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse
cell types and tissues. To enable systematic exploration of the programming landscape …

Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome

S Lago, M Nadai, FM Cernilogar, M Kazerani… - Nature …, 2021 - nature.com
Cell identity is maintained by activation of cell-specific gene programs, regulated by
epigenetic marks, transcription factors and chromatin organization. DNA G-quadruplex (G4) …

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

SC Baca, DY Takeda, JH Seo, J Hwang, SY Ku… - Nature …, 2021 - nature.com
Lineage plasticity, the ability of a cell to alter its identity, is an increasingly common
mechanism of adaptive resistance to targeted therapy in cancer. An archetypal example is …

A predictive computational framework for direct reprogramming between human cell types

OJL Rackham, J Firas, H Fang, ME Oates, ML Holmes… - Nature …, 2016 - nature.com
Transdifferentiation, the process of converting from one cell type to another without going
through a pluripotent state, has great promise for regenerative medicine. The identification of …

[HTML][HTML] CRISPR activation screens systematically identify factors that drive neuronal fate and reprogramming

Y Liu, C Yu, TP Daley, F Wang, WS Cao, S Bhate, X Lin… - Cell stem cell, 2018 - cell.com
Comprehensive identification of factors that can specify neuronal fate could provide valuable
insights into lineage specification and reprogramming, but systematic interrogation of …

Modeling gene regulation from paired expression and chromatin accessibility data

Z Duren, X Chen, R Jiang, Y Wang… - Proceedings of the …, 2017 - National Acad Sciences
The rapid increase of genome-wide datasets on gene expression, chromatin states, and
transcription factor (TF) binding locations offers an exciting opportunity to interpret the …

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization

A Kojic, A Cuadrado, M De Koninck… - Nature structural & …, 2018 - nature.com
Two variant cohesin complexes containing SMC1, SMC3, RAD21 and either SA1 (also
known as STAG1) or SA2 (also known as STAG2) are present in all cell types. We report …