The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …

The intestinal epithelium serves as a dynamic barrier to the environment and integrates a
variety of signals, including those from metabolites, commensal microbiota, immune …

Somatic stem cells constantly adjust their self-renewal and lineage commitment by
integrating various environmental cues to maintain tissue homeostasis. Although numerous …

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature
aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase …

Background & Aims Functions of intestinal stem cells (ISCs) are regulated by diet and
metabolic pathways. Hepatocyte nuclear factor 4 (HNF4) family are transcription factors that …

Aging constitutes the main risk factor for the development of neurodegenerative diseases.
This represents a major health issue worldwide that is only expected to escalate due to the …

A fundamental and unresolved question in regenerative biology is how tissues return to
homeostasis after injury. Answering this question is essential for understanding the …

Regenerative processes that maintain the function of the gastrointestinal (GI) epithelium are
critical for health and survival of multicellular organisms. In insects and vertebrates, intestinal …

Cellular senescence and the senescence-associated secretory phenotype (SASP) are
implicated in aging and age-related disease, and SASP-related inflammation is thought to …

Neural stem cells (NSCs) in the adult brain transit from the quiescent state to proliferation to
produce new neurons. The mechanisms regulating this transition in freely behaving animals …