Gastrointestinal-based drug delivery is considered the preferred mode of drug
administration owing to its convenience for patients, which improves adherence. However …

Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

The oral route is the most common and practical means of drug administration, particularly
from a patient's perspective. However, the pharmacokinetic profile of oral drugs depends on …

Abstract Background Bioactive peptides (BAPs) play a crucial physiological role in human
health. To exert their biological effects after oral administration, BAPs have to be transported …

Polysaccharides have been widely used as biomaterials and drugs after oral administration
due to their suitable physicochemical properties, good bioactivities and low toxicities …

Oral drug administration is one of the most preferred and simplest routes among both
patients and formulation scientists. Nevertheless, orally delivery of some of the most widely …

Oral absorption of protein/peptide-loaded nanoparticles is often limited by multiple barriers
of the intestinal epithelium. In addition to mucus translocation and apical endocytosis, highly …

Biological barriers are essential for the maintenance of homeostasis in health and disease.
Breakdown of the intestinal barrier is an essential aspect of the pathophysiology of …

The demand for highly efficient macromolecular drugs, used in the treatment of many severe
diseases, is continuously increasing. However, the hydrophilic character and large …

The objective of this work was the development of a new drug nanocarrier intended to
overcome the barriers associated to the oral modality of administration and to assess its …