Abstract The Coronavirus disease-19 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), has impacted human lives in the most …

Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …

Abstract N 6-methyladenosine (m6A) is the most abundant internal mRNA nucleotide
modification in mammals, regulating critical aspects of cell physiology and differentiation …

Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …

Abstract mRNA-based drugs have tremendous potential as clinical treatments, however, a
major challenge in realizing this drug class will promise to develop methods for safely …

Background mRNA vaccines hold great potential as therapeutic techniques against viral
infections due to their efficacy, safety, and large-scale production. mRNA vaccines offer …

Accurate and systematic transcriptome-wide detection of 5-methylcytosine (m5C) has
proved challenging, and there are conflicting views about the prevalence of this modification …

Post‐transcriptional regulation of messenger RNAs (mRNAs)(ie, mechanisms that control
translation, stability and localization) is a critical focal point in spatiotemporal regulation of …

Poly (A) tails are important elements in mRNA translation and stability, although recent
genome-wide studies have concluded that poly (A) tail length is generally not associated …

Translation and decay of eukaryotic mRNAs is controlled by shortening of the poly (A) tail
and release of the poly (A)-binding protein Pab1/PABP. The Ccr4-Not complex contains two …