[HTML][HTML] The lid domain in lipases: Structural and functional determinant of enzymatic properties
FI Khan, D Lan, R Durrani, W Huan, Z Zhao… - … in bioengineering and …, 2017 - frontiersin.org
Lipases are important industrial enzymes. Most of the lipases operate at lipid–water
interfaces enabled by a mobile lid domain located over the active site. Lid protects the active …
interfaces enabled by a mobile lid domain located over the active site. Lid protects the active …
Thermostable lipases and their dynamics of improved enzymatic properties
Thermal stability is one of the most desirable characteristics in the search for novel lipases.
The search for thermophilic microorganisms for synthesising functional enzyme biocatalysts …
The search for thermophilic microorganisms for synthesising functional enzyme biocatalysts …
Remdesivir strongly binds to RNA-dependent RNA polymerase, membrane protein, and main protease of SARS-CoV-2: indication from molecular modeling and …
Development of new drugs is a time-taking and expensive process. Comprehensive efforts
are being made globally toward the search of therapeutics against SARS-CoV-2. Several …
are being made globally toward the search of therapeutics against SARS-CoV-2. Several …
Investigation of molecular mechanism of recognition between citral and MARK4: A newer therapeutic approach to attenuate cancer cell progression
Microtubule affinity regulating kinase 4 (MARK4) is a member of AMP-activated protein
kinase, found to be involved in apoptosis, inflammation and many other regulatory …
kinase, found to be involved in apoptosis, inflammation and many other regulatory …
Identification and Evaluation of Inhibitors of Lipase from Malassezia restricta using Virtual High-Throughput Screening and Molecular Dynamics Studies
Recent studies revealed the role of lipase in the pathogenicity of Malassezia restricta in
dandruff and seborrheic dermatitis (D/SD). The lipase from M. restricta (Mrlip1) is considered …
dandruff and seborrheic dermatitis (D/SD). The lipase from M. restricta (Mrlip1) is considered …
Investigation of lipolytic-secreting bacteria from an artificially polluted soil using a modified culture method and optimization of their lipase production
Compared to lipases from plants or animals, microbial lipases play a vital role in different
industrial applications and biotechnological perspectives due to their high stability and cost …
industrial applications and biotechnological perspectives due to their high stability and cost …
High throughput screening, docking, and molecular dynamics studies to identify potential inhibitors of human calcium/calmodulin-dependent protein kinase IV
Calcium/calmodulin-dependent protein kinase IV (CAMKIV) is associated with many
diseases including cancer and neurodegenerative disorders and thus being considered as …
diseases including cancer and neurodegenerative disorders and thus being considered as …
Investigation of molecular interactions mechanism of pembrolizumab and PD-1
S Wang, FI Khan - International Journal of Molecular Sciences, 2023 - mdpi.com
Human programmed cell death protein 1 (PD-1) is a checkpoint protein involved in the
regulation of immune response. Antibodies are widely used as inhibitors that block the …
regulation of immune response. Antibodies are widely used as inhibitors that block the …
Binding mechanism of caffeic acid and simvastatin to the integrin linked kinase for therapeutic implications: a comparative docking and MD simulation studies
Integrin linked kinase (ILK) is a Ser/Thr kinase, which regulates various integrin mediated
signaling pathways, and is involved in cell adhesion, migration and differentiation. Alteration …
signaling pathways, and is involved in cell adhesion, migration and differentiation. Alteration …
Identifying novel sphingosine kinase 1 inhibitors as therapeutics against breast cancer
Abstract Sphingosine kinase 1 (SphK1) is a promising therapeutic target against several
diseases including mammary cancer. The aim of present work is to identify a potent lead …
diseases including mammary cancer. The aim of present work is to identify a potent lead …