Ageing, cellular senescence and neurodegenerative disease

M Kritsilis, S V. Rizou, PN Koutsoudaki… - International journal of …, 2018 - mdpi.com
Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

Flavonoids as prospective compounds for anti-cancer therapy

D Ravishankar, AK Rajora, F Greco… - The international journal …, 2013 - Elsevier
Flavonoids, which are polyphenolic compounds, are a class of plant secondary metabolites
possessing a broad spectrum of pharmacological activity including anti-cancer activities …

Distribution and biological activities of the flavonoid luteolin

M López-Lázaro - Mini reviews in medicinal chemistry, 2009 - ingentaconnect.com
Epidemiological evidence suggests that flavonoids may play an important role in the
decreased risk of chronic diseases associated with a diet rich in plant-derived foods …

[HTML][HTML] Senescence and senotherapeutics: a new field in cancer therapy

V Myrianthopoulos, K Evangelou, PVS Vasileiou… - Pharmacology & …, 2019 - Elsevier
Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal
activation during embryonic development or normal adult life is linked with beneficial …

Recent advances in small organic molecules as DNA intercalating agents: Synthesis, activity, and modeling

A Rescifina, C Zagni, MG Varrica, V Pistarà… - European journal of …, 2014 - Elsevier
The interaction of small molecules with DNA plays an essential role in many biological
processes. As DNA is often the target for majority of anticancer and antibiotic drugs, study …

Dual agents loaded PLGA nanoparticles: systematic study of particle size and drug entrapment efficiency

X Song, Y Zhao, S Hou, F Xu, R Zhao, J He… - European journal of …, 2008 - Elsevier
PLGA nanoparticles simultaneously loaded with vincristine sulfate (VCR) and quercetin
(QC) were prepared via O/W emulsion solvent evaporation. Six independent processing …

Fruitful decade for antileishmanial compounds from 2002 to late 2011

H Hussain, A Al-Harrasi, A Al-Rawahi, IR Green… - Chemical …, 2014 - ACS Publications
Leishmaniasis, usually caused by the genus Leishmania, has not received the attention it
deserves and in recent times has developed into a major health problem worldwide. 1, 2 …

Polyphenols and cancer cell growth

M Kampa, AP Nifli, G Notas, E Castanas - Reviews of physiology …, 2007 - Springer
Polyphenols constitute an important group of phytochemicals that gained increased
research attention since it was found that they could affect cancer cell growth. Initial …

Effective use of reducing agents and nanoparticle encapsulation in stabilizing catechins in alkaline solution

A Dube, K Ng, JA Nicolazzo, I Larson - Food chemistry, 2010 - Elsevier
Catechins are an important class of dietary flavonoids with promising use as therapeutic
agents due to their potent antioxidant activity and diverse biological properties. However …

MAX1, a regulator of the flavonoid pathway, controls vegetative axillary bud outgrowth in Arabidopsis

G Lazar, HM Goodman - Proceedings of the National …, 2006 - National Acad Sciences
We show that MAX1, a specific repressor of vegetative axillary bud outgrowth in Arabidopsis,
acts a positive regulator of the flavonoid pathway, including 11 structural genes and the …