Chikungunya virus: an emergent arbovirus to the South American continent and a continuous threat to the world

MS Cunha, PAG Costa, IA Correa… - Frontiers in …, 2020 - frontiersin.org
Chikungunya virus (CHIKV) is an arthropod-borne virus (arbovirus) of epidemic concern,
transmitted by Aedes ssp. mosquitoes, and is the etiologic agent of a febrile and …

Role of MAPK/MNK1 signaling in virus replication

R Kumar, N Khandelwal, R Thachamvally, BN Tripathi… - Virus research, 2018 - Elsevier
Viruses are obligate intracellular parasites; they heavily depend on the host cell machinery
to effectively replicate and produce new progeny virus particles. Following viral infection …

Discovery of widespread host protein interactions with the pre-replicated genome of CHIKV using VIR-CLASP

B Kim, S Arcos, K Rothamel, J Jian, KL Rose… - Molecular Cell, 2020 - cell.com
The primary interactions between incoming viral RNA genomes and host proteins are crucial
to infection and immunity. Until now, the ability to study these events was lacking. We …

The alphavirus exit pathway: what we know and what we wish we knew

RS Brown, JJ Wan, M Kielian - Viruses, 2018 - mdpi.com
Alphaviruses are enveloped positive sense RNA viruses and include serious human
pathogens, such as the encephalitic alphaviruses and Chikungunya virus. Alphaviruses are …

Chikungunya virus dissemination from the midgut of Aedes aegypti is associated with temporal basal lamina degradation during bloodmeal digestion

S Dong, V Balaraman, AM Kantor, J Lin… - PLoS neglected …, 2017 - journals.plos.org
In the mosquito, the midgut epithelium is the initial tissue to become infected with an
arthropod-borne virus (arbovirus) that has been acquired from a vertebrate host along with a …

Actin-related protein 2 (ARP2) and virus-induced filopodia facilitate human respiratory syncytial virus spread

M Mehedi, T McCarty, SE Martin, C Le Nouën… - PLoS …, 2016 - journals.plos.org
Human respiratory syncytial virus (RSV) is an enveloped RNA virus that is the most
important viral cause of acute pediatric lower respiratory tract illness worldwide, and lacks a …

Understanding host responses to equine encephalitis virus infection: implications for therapeutic development

K Kehn-Hall, SB Bradfute - Expert Review of Anti-infective Therapy, 2022 - Taylor & Francis
Introduction Venezuelan, eastern, and western equine encephalitis viruses (VEEV, EEEV,
and WEEV) are mosquito-borne New World alphaviruses that cause encephalitis in equids …

Chikungunya virus nsP1 induces migrasome formation

N Zhang, S Gao, L Zhang - Journal of Infection, 2022 - journalofinfection.com
In this journal, Quintão et al. reporting the detection of Chikungunya virus (CHIKV) infection
by viral metagenomics. 1 CHIKV is a member of the genus Alphavirus in the family …

Intercellular extensions are induced by the alphavirus structural proteins and mediate virus transmission

MG Martinez, M Kielian - PLoS pathogens, 2016 - journals.plos.org
Alphaviruses are highly organized enveloped RNA viruses with an internal nucleocapsid
surrounded by a membrane containing the E2 and E1 transmembrane proteins. Alphavirus …

Mayaro virus: The state-of-the-art for antiviral drug development

AP Andreolla, AA Borges, J Bordignon… - Viruses, 2022 - mdpi.com
Mayaro virus is an emerging arbovirus that causes nonspecific febrile illness or arthralgia
syndromes similar to the Chikungunya virus, a virus closely related from the Togaviridae …