Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

Since the identification in 1988 of bone morphogenetic protein 2 (BMP2) as a potent inducer
of bone and cartilage formation, BMP superfamily signalling has become one of the most …

Chondrogenesis results in the formation of cartilages, initial skeletal elements that can serve
as templates for endochondral bone formation. Cartilage formation begins with the …

The reaction patterns of chondrocytes in osteoarthritis can be summarized in five
categories:(1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and …

The identification of mutations in the SRY-related SOX9 gene in patients with campomelic
dysplasia, a severe skeletal malformation syndrome, and the abundant expression of Sox9 …

Objective Functional suitability and phenotypic stability of ectopic transplants are crucial
factors in the clinical application of mesenchymal stem cells (MSCs) for articular cartilage …

We describe the isolation of a nonhematopoietic (CD45−, CD34−, SH2+, SH3+, Thy‐1+,
CD44+) human umbilical cord perivascular (HUCPV) cell population. Each HUCPV cell …

Mesenchymal progenitor cells provide a source of cells for the repair of musculoskeletal
tissue. However, in vitro models are needed to study the mechanisms of differentiation of …

Transcripts for a new form of Sox5, called L-Sox5, and Sox6 are coexpressed with Sox9 in
all chondrogenic sites of mouse embryos. A coiled-coil domain located in the N-terminal part …

To examine the relationship between growth hormone (GH) and insulin-like growth factor 1
(IGF1) in controlling postnatal growth, we performed a comparative analysis of dwarfing …