Role of transgenic plants in agriculture and biopharming

P Ahmad, M Ashraf, M Younis, X Hu, A Kumar… - Biotechnology …, 2012 - Elsevier
At present, environmental degradation and the consistently growing population are two main
problems on the planet earth. Fulfilling the needs of this growing population is quite difficult …

Emerging antibody products and Nicotiana manufacturing

KJ Whaley, A Hiatt, L Zeitlin - Human vaccines, 2011 - Taylor & Francis
Antibody based products are not widely available to address multiple global health
challenges due to high costs, limited manufacturing capacity, and long manufacturing lead …

Chloroplast‐derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery

A Davoodi‐Semiromi, M Schreiber… - Plant biotechnology …, 2010 - Wiley Online Library
Cholera and malaria are major diseases causing high mortality. The only licensed cholera
vaccine is expensive; immunity is lost in children within 3 years and adults are not fully …

Carrot cells: a pioneering platform for biopharmaceuticals production

S Rosales-Mendoza, MA Tello-Olea - Molecular biotechnology, 2015 - Springer
Carrot (Daucus carota L.) is of importance in the molecular farming field as it constitutes the
first plant species approved to produce biopharmaceuticals for human use. In this review …

Recent development and future prospects of plant-based vaccines

S Sartaj Sohrab, M Suhail, M A. Kamal… - Current drug …, 2017 - benthamdirect.com
Background: Growing world population and continuous disease emergence have invited the
development of more efficient new vaccines against a range of diseases. Conventional …

The last ten years of advancements in plant-derived recombinant vaccines against hepatitis B

YH Joung, SH Park, KB Moon, JH Jeon… - International Journal of …, 2016 - mdpi.com
Disease prevention through vaccination is considered to be the greatest contribution to
public health over the past century. Every year more than 100 million children are …

Using carrot cells as biofactories and oral delivery vehicles of LTB-Syn: A low-cost vaccine candidate against synucleinopathies

JI Arevalo-Villalobos, DOG Alonso… - Journal of …, 2020 - Elsevier
Synucleinopathies are conditions that remain with no available effective treatments thus far.
Immunotherapy is a possible path to fight against such pathologies by inducing antibodies …

Assessing the efficiency of SBA-15 as a nanocarrier for diphtheria anatoxin

MK Rasmussen, HN Bordallo, MA Bordenalli… - Microporous and …, 2021 - Elsevier
SBA-15 ordered mesoporous silica can be considered a promising inorganic nanocarrier
with emerging potential as an oral vaccine adjuvant. In this study, we investigated its …

Heterologous expression of recombinant proteins and their derivatives used as carriers for conjugate vaccines

YA Khodak - Biochemistry (Moscow), 2023 - Springer
Carrier proteins that provide an effective and long-term immune response to weak antigens
has become a real breakthrough in the disease prevention, making it available to a wider …

High-Level Production of Soluble Cross-Reacting Material 197 in Escherichia coli Cytoplasm Due to Fine Tuning of the Target Gene's mRNA Structure

YA Khodak, AY Ryazanova, II Vorobiev, AL Kovalchuk… - BioTech, 2023 - mdpi.com
Cross-reacting material 197 (CRM197) is a non-toxic mutant of the diphtheria toxin and is
widely used as a carrier protein in conjugate vaccines. This protein was first obtained from …