Post-translational modifications of G Protein–Coupled receptors control cellular signaling dynamics in space and time
G protein–coupled receptors (GPCRs) are a large family comprising> 800 signaling
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
Regulation of GPCRs by endocytic membrane trafficking and its potential implications
AC Hanyaloglu, M Zastrow - Annu. Rev. Pharmacol. Toxicol., 2008 - annualreviews.org
The endocytic pathway tightly controls the activity of G protein–coupled receptors (GPCRs).
Ligand-induced endocytosis can drive receptors into divergent lysosomal and recycling …
Ligand-induced endocytosis can drive receptors into divergent lysosomal and recycling …
G protein–coupled receptor sorting to endosomes and lysosomes
A Marchese, MM Paing, BRS Temple… - Annu. Rev. Pharmacol …, 2008 - annualreviews.org
The heptahelical G protein–coupled receptors (GPCRs) belong to the largest family of cell
surface signaling receptors encoded in the human genome. GPCRs signal to diverse …
surface signaling receptors encoded in the human genome. GPCRs signal to diverse …
Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease: many pathways to neurodegeneration
DA Butterfield, SS Hardas… - Journal of Alzheimer's …, 2010 - content.iospress.com
Abstract Recently, the oxidoreductase, glyceraldehyde-3-phosphate dehydrogenase
(GAPDH), has become a subject of interest as more and more studies reveal a surfeit of …
(GAPDH), has become a subject of interest as more and more studies reveal a surfeit of …
Ubiquitination in postsynaptic function and plasticity
AM Mabb, MD Ehlers - Annual review of cell and developmental …, 2010 - annualreviews.org
Neurons are highly specialized cells whose connectivity at synapses subserves rapid
information transfer in the brain. Proper information processing, learning, and memory …
information transfer in the brain. Proper information processing, learning, and memory …
Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses
Shank3/PROSAP2 gene mutations are associated with cognitive impairment ranging from
mental retardation to autism. Shank3 is a large scaffold postsynaptic density protein …
mental retardation to autism. Shank3 is a large scaffold postsynaptic density protein …
Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation
CL Waites, SA Leal‐Ortiz, N Okerlund, H Dalke… - The EMBO …, 2013 - embopress.org
The presynaptic active zone (AZ) is a specialized microdomain designed for the efficient and
repetitive release of neurotransmitter. Bassoon and Piccolo are two high molecular weight …
repetitive release of neurotransmitter. Bassoon and Piccolo are two high molecular weight …
[HTML][HTML] Membrane trafficking and positioning of mGluRs at presynaptic and postsynaptic sites of excitatory synapses
A Bodzęta, N Scheefhals, HD MacGillavry - Neuropharmacology, 2021 - Elsevier
The plethora of functions of glutamate in the brain are mediated by the complementary
actions of ionotropic and metabotropic glutamate receptors (mGluRs). The ionotropic …
actions of ionotropic and metabotropic glutamate receptors (mGluRs). The ionotropic …
Nitric oxide–GAPDH–Siah: a novel cell death cascade
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an extremely abundant glycolytic
enzyme, and exemplifies the class of proteins with multiple, seemingly unrelated functions …
enzyme, and exemplifies the class of proteins with multiple, seemingly unrelated functions …
Role of ubiquitylation in cellular membrane transport
Ubiquitylation of membrane proteins has gained considerable interest in recent years. It has
been recognized as a signal that negatively regulates the cell surface expression of many …
been recognized as a signal that negatively regulates the cell surface expression of many …