The scientific landscape surrounding amyotrophic lateral sclerosis (ALS) continues to shift
as the number of genes associated with the disease risk and pathogenesis, and the cellular …

Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …

Considerable progress has been made in unraveling the genetic etiology of amyotrophic
lateral sclerosis (ALS), the most common form of adult-onset motor neuron disease and the …

Breakthrough discoveries identifying common genetic causes for amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD) have transformed our view of these …

Frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative
disorders with different pathological signatures, genetic variability and complex disease …

The removal of misfolded, ubiquitinated proteins is an essential part of the protein quality
control. The ubiquitin‐proteasome system (UPS) and autophagy are two interconnected …

Autophagy is a major intracellular degradative process that delivers cytoplasmic materials to
the lysosome for degradation. Since the discovery of autophagy-related (Atg) genes in the …

Mechanisms of protein homeostasis are crucial for overseeing the clearance of misfolded
and toxic proteins over the lifetime of an organism, thereby ensuring the health of neurons …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease predominantly affecting
upper and lower motor neurons. The disease leads to relentlessly progressive weakness of …

Our understanding of the process of autophagy and its role in health and diseases has
grown remarkably in the last two decades. Early work established autophagy as a general …