Our incomplete understanding of the causes and pathways involved in the onset and
progression of multiple sclerosis (MS) limits our ability to effectively treat this complex …

Novel insights from basic and translational studies are reshaping concepts of the
immunopathogenesis of multiple sclerosis and understanding of the different inflammatory …

The adaptive immune system and associated inflammation are vital in surveillance and host
protection against internal and external threats, but can secondarily damage host tissues …

Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved T cell subset,
which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of …

A small proportion of multiple sclerosis (MS) patients develop new disease activity soon after
starting anti-CD20 therapy. This activity does not recur with further dosing, possibly reflecting …

Multiple sclerosis (MS) is a frequent autoimmune demyelinating disease of the central
nervous system (CNS). There are three clinical forms described: relapsing-remitting multiple …

The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …

New so-called immune reconstitution therapies (IRTs) have the potential to induce long-term
or even permanent drug-free remission in people with multiple sclerosis (MS). These …

Abstract IL-17-producing CD8+ (Tc17) cells are enriched in active lesions of patients with
multiple sclerosis (MS), suggesting a role in the pathogenesis of autoimmunity. Here we …

Multiple sclerosis (MS) is a chronic, autoimmune, and neurodegenerative disease of the
central nervous system (CNS) that affects myelin. The etiology of MS is unclear, although a …