Genetic landscape of papillary thyroid carcinoma and nuclear architecture: an overview comparing pediatric and adult populations
A Rangel-Pozzo, L Sisdelli, MIV Cordioli, F Vaisman… - Cancers, 2020 - mdpi.com
Simple Summary Papillary thyroid carcinoma (PTC) represents 80–90% of all differentiated
thyroid carcinomas. PTC has a high rate of gene fusions and mutations, which can influence …
thyroid carcinomas. PTC has a high rate of gene fusions and mutations, which can influence …
[HTML][HTML] Molecular characterization of cancers with NTRK gene fusions
Z Gatalica, J Xiu, J Swensen, S Vranic - Modern Pathology, 2019 - Elsevier
Targeted inhibitors of neurotropic tyrosine kinases are highly effective in selected patients
with gene fusions involving NTRK1, NTRK2, or NTRK3. These fusions are consistently …
with gene fusions involving NTRK1, NTRK2, or NTRK3. These fusions are consistently …
Molecular genetics of follicular-derived thyroid cancer
E Macerola, AM Poma, P Vignali, A Basolo, C Ugolini… - Cancers, 2021 - mdpi.com
Simple Summary Thyroid tumors that derive from follicular cells are not a homogeneous
entity, showing variable morphological appearance and different degrees of differentiation …
entity, showing variable morphological appearance and different degrees of differentiation …
RET, NTRK, ALK, BRAF, and MET Fusions in a Large Cohort of Pediatric Papillary Thyroid Carcinomas
B Pekova, V Sykorova, S Dvorakova, E Vaclavikova… - Thyroid, 2020 - liebertpub.com
Background: Pediatric papillary thyroid carcinoma (PTC) is a rare malignancy, but with
increasing incidence. Pediatric PTCs have distinct clinical and pathological features and …
increasing incidence. Pediatric PTCs have distinct clinical and pathological features and …
Detection of NTRK1/3 Rearrangements in Papillary Thyroid Carcinoma Using Immunohistochemistry, Fluorescent In Situ Hybridization, and Next-Generation …
YC Lee, JY Chen, CJ Huang, HS Chen, AH Yang… - Endocrine …, 2020 - Springer
NTRK1/3 rearrangements have been reported in 2.3–3.4% of papillary thyroid carcinoma
(PTC) and are regarded as potential therapeutic targets. Recently, the application of …
(PTC) and are regarded as potential therapeutic targets. Recently, the application of …
Characterization of thyroid cancer driven by known and novel ALK fusions
F Panebianco, AV Nikitski… - Endocrine-related …, 2019 - erc.bioscientifica.com
ALK fusions are found in various tumors, including thyroid cancer, and serve as a diagnostic
marker and therapeutic target. Spectrum and outcomes of ALK fusions found in thyroid …
marker and therapeutic target. Spectrum and outcomes of ALK fusions found in thyroid …
Clinical use of molecular data in thyroid nodules and cancer
AS Alzahrani - The Journal of Clinical Endocrinology & …, 2023 - academic.oup.com
Over the past 3 decades, advances in the molecular genetics of thyroid cancer (TC) have
been translated into diagnostic tests, prognostic markers, and therapeutic agents. The main …
been translated into diagnostic tests, prognostic markers, and therapeutic agents. The main …
Diverse oncogenic fusions and distinct gene expression patterns define the genomic landscape of pediatric papillary thyroid carcinoma
Pediatric papillary thyroid carcinoma (PPTC) is clinically distinct from adult-onset disease.
Although there are higher rates of metastasis and recurrence in PPTC, prognosis remains …
Although there are higher rates of metastasis and recurrence in PPTC, prognosis remains …
Influencers on thyroid cancer onset: molecular genetic basis
B Luzón-Toro, RM Fernández, L Villalba-Benito… - Genes, 2019 - mdpi.com
Thyroid cancer, a cancerous tumor or growth located within the thyroid gland, is the most
common endocrine cancer. It is one of the few cancers whereby incidence rates have …
common endocrine cancer. It is one of the few cancers whereby incidence rates have …
Kinase Fusion–Related Thyroid Carcinomas: Towards Predictive Models for Advanced Actionable Diagnostics
The past decade has brought significant advances in our understanding of the molecular
mechanisms of thyroid carcinogenesis. Among thyroid carcinomas, the most successful …
mechanisms of thyroid carcinogenesis. Among thyroid carcinomas, the most successful …