Drug conjugates are chemotherapeutic or cytotoxic agents covalently linked to targeting
ligands such as an antibody or a peptide via a linker. While antibody–drug conjugates …

▪ Abstract Multiple carboxylesterases (EC 3.1. 1.1) play an important role in the hydrolytic
biotransformation of a vast number of structurally diverse drugs. These enzymes are major …

Chemotherapeutic nanomedicines can exploit the neighboring effect to increase tumor
penetration. However, the neighboring effect is limited, likely by the consumption of …

Many drugs and other xenobiotics (eg, preservatives, insecticides, and plastifiers) contain
hydrolyzable moieties such as ester or amide groups. In biological media, such foreign …

Antibody− drug conjugates (ADCs) were prepared with potent camptothecin analogues
attached to monoclonal antibodies (mAbs) via dipeptide or glucuronide-based linkers …

Metabolism and other pharmacokinetic (PK) studies have always played a critical role in
helping to optimize the bioavailability and duration of action of new drugs thereby increasing …

Acetylcholinesterase (AChE) activity has traditionally been monitored as a biomarker of
organophosphate (OP) and/or carbamate exposure. However, AChE activity may not be the …

Antibody–drug conjugates (ADCs) offer increased efficacy and reduced toxicity compared to
systemic chemotherapy. Less attention has been paid to peptide–drug delivery, which has …

Photoremovable protecting groups are important for a wide range of applications in peptide
chemistry. Using Fmoc-Cys (Bhc-MOM)-OH, peptides containing a Bhc-protected cysteine …

AIDS is a pandemic disease caused by HIV that affects 37 million people worldwide. Current
antiretroviral therapy slows disease progression but does not eliminate latently infected …