Glioblastoma stem cells—useful tools in the battle against cancer
SMB Rodriguez, GA Staicu, AS Sevastre… - International Journal of …, 2022 - mdpi.com
Glioblastoma stem cells (GSCs) are cells with a self-renewal ability and capacity to initiate
tumors upon serial transplantation that have been linked to tumor cell heterogeneity. Most …
tumors upon serial transplantation that have been linked to tumor cell heterogeneity. Most …
Hydroxamic acid derivatives as selective HDAC3 inhibitors: computer-aided drug design strategies
P Patel, SK Shrivastava, P Sharma… - Journal of …, 2024 - Taylor & Francis
Histone deacetylases (HDACs) are critical epigenetic drug targets that have gained
significant attention in the scientific community for the treatment of cancer. The currently …
significant attention in the scientific community for the treatment of cancer. The currently …
Identification of dietary bioflavonoids as potential inhibitors against KRAS G12D mutant—novel insights from computer-aided drug discovery
PS Ramalingam, P Balakrishnan, S Rajendran… - Current Issues in …, 2023 - mdpi.com
The KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and
lung, and has remained undruggable for the past three decades, due to its smooth surface …
lung, and has remained undruggable for the past three decades, due to its smooth surface …
[HTML][HTML] The Role of HDAC6 in Glioblastoma Multiforme: A New Avenue to Therapeutic Interventions?
F Spallotta, B Illi - Biomedicines, 2024 - mdpi.com
Despite the great advances in basic research results, glioblastoma multiforme (GBM) still
remains an incurable tumour. To date, a GBM diagnosis is a death sentence within 15–18 …
remains an incurable tumour. To date, a GBM diagnosis is a death sentence within 15–18 …
Purification, characterization, and biological activities of melanin pigment isolated from Indian squid Uroteuthis duvaucelii
S Elangovan, S Arumugam - Aquaculture International, 2023 - Springer
Melanin is a natural pigment present in plants, animals, humans, and pigment-producing
bacteria. Due to their biocompatibility and versatile biological activities, it was heavily used …
bacteria. Due to their biocompatibility and versatile biological activities, it was heavily used …
A green one-pot synthetic protocol of hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one derivatives: molecular docking, ADMET, anticancer and antimicrobial studies
Abstract Ten hexahydropyrimido [4, 5-d] pyrimidine derivatives have been synthesized by
using a green and time-efficient microwave method. The synthesized motifs were evaluated …
using a green and time-efficient microwave method. The synthesized motifs were evaluated …
Design, synthesis, biological evaluation and molecular docking study of novel quinolone derivatives as potent HDAC1 (Histone Deacetylase) inhibitors and anticancer …
Histone deacetylases (HDACs), especially HDAC1, are attractive targets for anticancer drug
design because of their significant role in transcriptional repression and chromatin …
design because of their significant role in transcriptional repression and chromatin …
Computational identification and experimental validation of potential inhibitors of JAK1 kinase from natural source for the effective treatment of colorectal …
Colorectal cancer (CRC) has become a global threat worldwide with constantly increasing
incidence and mortality rates every year, especially in the US and China. Janus kinase …
incidence and mortality rates every year, especially in the US and China. Janus kinase …
Synthesis of 8-methyl-2-phenylquinazolin-4 (3H)-ones derived Schiff's bases: Spectroscopic properties, SAR, docking approaches and their anticancer and …
A series of new compounds based on 8-methyl-2-phenyl quinazolinone Schiff's base were
synthesized from 3-amino quinazolinone intermediates. These compounds were evaluated …
synthesized from 3-amino quinazolinone intermediates. These compounds were evaluated …
[HTML][HTML] Non-nucleophilic base promoted synthesis of azo-linked oxazolone-pyrazole hybrids: Antimicrobial, antitubercular, anticancer evaluations and in-silico …
Ten new non-nucleophilic base (DBU) catalyzed oxazolone-bearing pyrazole derivatives
were created to treat infectious diseases caused by bacterial, mycobacterial strains, and …
were created to treat infectious diseases caused by bacterial, mycobacterial strains, and …