Cell signaling via inositol phosphates, in particular via the second messenger myo‐inositol
1, 4, 5‐trisphosphate, and phosphoinositides comprises a huge field of biology. Of the nine …

Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …

Metabolomics by gas chromatography/mass spectrometry (GC/MS) provides a standardized
and reliable platform for understanding small molecule biology. Since 2005, the West Coast …

All cells rely on nutrients to supply energy and carbon building blocks to support cellular
processes. Over time, eukaryotes have developed increasingly complex systems to integrate …

The present study evaluated the anti-obesity effect of sulforaphane (SFN) and
glucoraphanin (GRN) in broccoli leaf extract (BLE) on 3T3-L1 adipocytes and ob/ob mice …

Obesity and obesity-induced metabolic dysfunctions are significant risk factors for
nonalcoholic fatty liver disease and cardiovascular diseases. Thus, obesity is an economic …

Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling
metabolites whose versatile modes of action are being increasingly appreciated. These …

Inositol pyrophosphates, such as diphospho-myo-inositol pentakisphosphates (InsP7), are
an important family of signalling molecules, implicated in many cellular processes and …

Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7)
are inositol metabolites containing high-energy phosphoanhydride bonds. Biosynthesis of …

The antifungal drug itraconazole has been repurposed to anti-angiogenic agent, but the
mechanisms of action have been elusive. Here we report that itraconazole disrupts focal …